Waldenstroms Macroglobulinemia- Diagnostic difficulties- a rare case report

Authors

  • Majed Momin Consultant Pathologist,Yashoda Hospital, Malakpet, Nalgonda x-roads, Hyderabad – 500036, India
  • Anamika Aluri Consultant biochemist & HOD Lab, Yashoda Hospital, Malakpet, Nalgonda x-roads, Hyderabad – 500036, India

DOI:

https://doi.org/10.3329/bjms.v18i3.41645

Keywords:

Waldenstroms Macroglobulinemia; PS/BM morphology; Flow cytometry; Immunofixation study

Abstract

Waldenstrom’s macroglobulinemia(WM) is a B-cell neoplasm characterized by infiltration of the bone marrow by a lymphoplasmacytic infiltrate and an IgM monoclonal gammopathy. We report a rare case of a 72 year-old male who presented with fever, shortness of breath for one month. Examination revealed cervical and axillary lymphadenopathy with mild hepatomegaly. On evaluation, peripheral smear show significant rouleaux formation & bone marrow aspiration showed lymphoplasmacytic infiltration. Flow cytometry on bone marrow apirate suggestive of B cell neoplasm and serum protein electophoresis & Immunofixation study confirms diagnosis of waldenstroms macroglobulinemia. We report this case to emphasize diagnostic difficulties in diagnosis of waldenstorms macroglobulinemia and application of flow cytometry and immunofixation study for further confirmation and treatment.

Bangladesh Journal of Medical Science Vol.18(3) 2019 p.656-659

Downloads

Download data is not yet available.
Abstract
23
PDF
41

Downloads

Published

2019-05-30

How to Cite

Momin, M., & Aluri, A. (2019). Waldenstroms Macroglobulinemia- Diagnostic difficulties- a rare case report. Bangladesh Journal of Medical Science, 18(3), 656–659. https://doi.org/10.3329/bjms.v18i3.41645

Issue

Vol. 18 No. 3 (2019)

Section

Case Reports

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.