Anthelmintic activity of Majoon Sarakhs on Earthworm

Authors

  • Ghausia Islam Nasreen Jahan, Dept. of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Bengaluru, India
  • Nasreen Jahan Dept. of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Bengaluru, India

DOI:

https://doi.org/10.3329/bjms.v19i4.46622

Keywords:

Albendazole; Anthelmintic; Earthworms; Intestinal helminthiasis; MajoonSarakhs

Abstract

Objective: Toevaluate the anthelmintic activity of Majoon Sarakhs, a pharmacopoeal Unani formulationonadult earthworm(Eiseniafetida).

Methods: Adult earthworms of similar age, size and weight were divided into six groups of 6 each and released in petridishes containing 0.5% CMC in normal saline (control), Albendazole (standard), hydro alcoholic extract (HAEMS), aqueous extract (AEMS), Majoon (MS) and powder (PFMS) of ingredients of MajoonSarakhs in various concentrations (50, 100, 150, 200, 250 and 300 mg/ml). Time for paralysis was noted when no movement was observed. Death was confirmed when the worms neither moved when shaken vigorously nor when dipped in warm water followed by fading away the body colours. Phytochemical analysis and HPLC finger printing were also carried out.

Results: All dosage forms of ingredients of MS showed significant anthelmintic (p<0.001) effect in concentration dependent manner when compared to Albendazole. The test formulation paralysed and killed the worms at all concentration, but at higher concentration it took shorter time. The order of activity was HAEMS > AEMS > Albendazole > MS > PFMS at 50mg/ml.At higher dose MS showed better results than Albendazole.

Conclusion: on the basis of above results it can be concluded that MS and extracts of its ingredients possess profound anthelmintic activity against tested worms. It validates the claims of Unani physicians that MS is a good anthelmintic agent.

Bangladesh Journal of Medical Science Vol.19(4) 2020 p.659-669

Downloads

Download data is not yet available.
Abstract
1
PDF
0

Downloads

Published

2020-04-12

How to Cite

Islam, G., & Jahan, N. (2020). Anthelmintic activity of Majoon Sarakhs on Earthworm. Bangladesh Journal of Medical Science, 19(4), 659–669. https://doi.org/10.3329/bjms.v19i4.46622

Issue

Vol. 19 No. 4 (2020)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.