Estimation of serum ferritin and TSH levels in thalassemia patients undergoing iron chelation therapy

Authors

  • Soma Ghosh Associate Professor, dept. of pathology, Burdwan Medical College, Burdwan, India
  • Dwaipayan Chakrabarti Postgraduate trainee, dept. of pathology, Burdwan Medical College, Burdwan, India

DOI:

https://doi.org/10.3329/bjms.v20i1.50357

Keywords:

Thalassemia; iron; chelation; ferritin; TSH

Abstract

Objectives & introduction: Thalassemia, heterogenous group of disorders of haemoglobin,characterised by reduced or absent production of one or more of globin chains.Regular redcell transfusion with chelation therapy for iron overload are cornerstones of therapy for ßthalassemia major. Serum ferritin assay is widely available, relatively inexpensive methodfor assessing body iron burden and monitoring response to chelation process which in turnalso improves TSH levels in thalassemic subjects .The objective of this study was to assessprechelation and postchelation levels of serum ferritin and TSH and correlating post chelationlevels of serum ferritin and TSH in thalassemic patients >6yrs undergoing chelation therapy.

Materials & methods: Serum TSH measured by Enzyme linked fluorescent assay and serumferritin measured by enzyme linked immunosorbent assay.

Results: Amongst 500 participants,47% were males & 53% females. Mean age was 9.04 yrs ;prechelation ferritin and TSH levelswere 2995.78ng/ml with SD of 802.53 and 5.07 μU/ml with SD of 2.52. The postchelationferritin and TSH levels were 2168.80 ng/ml with SD of 1335.89 and 4.51μU/ml with SD of4.76. Paired t test with respect to pre and postchelation ferritin and TSH levels showed 2 tailed pas 0.000 and t>3, both of which considered significant. While correlating post chelation ferritinwith TSH levels; they showed a linear correlation ( Pearson coefficient of .836).

Conclusion:Serum ferritin and TSH estimation in prechelation and postchelation periods give an estimateof iron overload with effect of chelation on it. Both levels decrease post chelation presenting alinear correlation between the two.

Bangladesh Journal of Medical Science Vol.20(1) 2021 p.130-135

Downloads

Download data is not yet available.
Abstract
17
PDF
29

Downloads

Published

2021-01-01

How to Cite

Ghosh, S., & Chakrabarti, D. (2021). Estimation of serum ferritin and TSH levels in thalassemia patients undergoing iron chelation therapy. Bangladesh Journal of Medical Science, 20(1), 130–135. https://doi.org/10.3329/bjms.v20i1.50357

Issue

Vol. 20 No. 1 (2021)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.