Role of cytokines in Granulomatous Colitis

Authors

  • Keya Basu Associate Professor, Dept of Gastroenterology, School of Digestive and Liver Diseases, IPGMER, Kolkata, India
  • Sucharita Sarkar Senior resident, Dept of Gastroenterology, School of Digestive and Liver Diseases, IPGMER, Kolkata, India
  • Subhrajyoti Karmakar Senior resident, Dept of Gastroenterology, School of Digestive and Liver Diseases, IPGMER, Kolkata, India
  • Dipan Das Senior resident, Dept of Gastroenterology, School of Digestive and Liver Diseases, IPGMER, Kolkata, India
  • Chhanda Das Assistant Professor, Dept of Gastroenterology, School of Digestive and Liver Diseases, IPGMER, Kolkata, India
  • Rajib Sarkar Assistant Professor Dept of Gastroenterology, School of Digestive and Liver Diseases, IPGMER, Kolkata, India

DOI:

https://doi.org/10.3329/bjms.v20i4.54135

Keywords:

tuberculosis; Crohn’s disease; cytokines; CD4 T cells; granulomatuos; inflammatory bowel diseases

Abstract

Background: Intestinal tuberculosis (ITB) have significant immunological similarity with Crohn’s disease (CD). T helper cells and various cytokines secreted by them play a very crucial role in the pathogenesis of both the diseases. It is of great clinical relevance in a country like India to perform a comparative study between CD and ITB with respect to pathogenesis.

Objectives: To study the levels of four cytokines(IL-4,IL-17, IFN-ϒ & TGF-β1 ) s in serum of patients with CD & ITB which indirectly reflects the levels of CD4+ T cells.

Material and method: An observational, cross-sectional study was done on patients, attending Gastroenterolory clinic in a tertiary care hospital, with features of ileitis, colitis or ileo-colitis due to CD or ITB.12 cases of Crohn’s disease & 13 cases of intestinal tuberculosis were taken( control-20 cases). 5 biopsies were taken from the ulcerated mucosa & 3 biopsies were taken from normal mucosa. H & E study & serum levels of four cytokines(IL-4,IL-17, IFN-ϒ & TGF-β1 ) were estimated.

Results & analysis: In CD & ITB we found marginal increase of IFN-ϒ & TGF-β1 compared to control. IL17 level was found decreased in ITB compared to control (p=0.001).CD4+ T cells study by ELISA also showed significant increase in the concentration of IFN-γ (p=0.007) in ITB. There was no change in IL4 levels.

Conclusion: Cytokines have an important role in the pathogenesis of grannulomatuos inflammatory bowel diseases. The identification of cytokines & their role in the pathogenesis might be helpful for future therapy based on cytokines, and anti-cytokine antibodies.

Bangladesh Journal of Medical Science Vol.20(4) 2021 p.784-789

Downloads

Download data is not yet available.
Abstract
23
PDF
38

Downloads

Published

2021-06-18

How to Cite

Basu, K., Sarkar, S., Karmakar, S., Das, D., Das, C., & Sarkar, R. (2021). Role of cytokines in Granulomatous Colitis. Bangladesh Journal of Medical Science, 20(4), 784–789. https://doi.org/10.3329/bjms.v20i4.54135

Issue

Vol. 20 No. 4 (2021)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.