Role of cytokines in Granulomatous Colitis

Authors

  • Keya Basu Associate Professor, Dept of Gastroenterology, School of Digestive and Liver Diseases, IPGMER, Kolkata, India
  • Sucharita Sarkar Senior resident, Dept of Gastroenterology, School of Digestive and Liver Diseases, IPGMER, Kolkata, India
  • Subhrajyoti Karmakar Senior resident, Dept of Gastroenterology, School of Digestive and Liver Diseases, IPGMER, Kolkata, India
  • Dipan Das Senior resident, Dept of Gastroenterology, School of Digestive and Liver Diseases, IPGMER, Kolkata, India
  • Chhanda Das Assistant Professor, Dept of Gastroenterology, School of Digestive and Liver Diseases, IPGMER, Kolkata, India
  • Rajib Sarkar Assistant Professor Dept of Gastroenterology, School of Digestive and Liver Diseases, IPGMER, Kolkata, India

DOI:

https://doi.org/10.3329/bjms.v20i4.54135

Keywords:

tuberculosis; Crohn’s disease; cytokines; CD4 T cells; granulomatuos; inflammatory bowel diseases

Abstract

Background: Intestinal tuberculosis (ITB) have significant immunological similarity with Crohn’s disease (CD). T helper cells and various cytokines secreted by them play a very crucial role in the pathogenesis of both the diseases. It is of great clinical relevance in a country like India to perform a comparative study between CD and ITB with respect to pathogenesis.

Objectives: To study the levels of four cytokines(IL-4,IL-17, IFN-ϒ & TGF-β1 ) s in serum of patients with CD & ITB which indirectly reflects the levels of CD4+ T cells.

Material and method: An observational, cross-sectional study was done on patients, attending Gastroenterolory clinic in a tertiary care hospital, with features of ileitis, colitis or ileo-colitis due to CD or ITB.12 cases of Crohn’s disease & 13 cases of intestinal tuberculosis were taken( control-20 cases). 5 biopsies were taken from the ulcerated mucosa & 3 biopsies were taken from normal mucosa. H & E study & serum levels of four cytokines(IL-4,IL-17, IFN-ϒ & TGF-β1 ) were estimated.

Results & analysis: In CD & ITB we found marginal increase of IFN-ϒ & TGF-β1 compared to control. IL17 level was found decreased in ITB compared to control (p=0.001).CD4+ T cells study by ELISA also showed significant increase in the concentration of IFN-γ (p=0.007) in ITB. There was no change in IL4 levels.

Conclusion: Cytokines have an important role in the pathogenesis of grannulomatuos inflammatory bowel diseases. The identification of cytokines & their role in the pathogenesis might be helpful for future therapy based on cytokines, and anti-cytokine antibodies.

Bangladesh Journal of Medical Science Vol.20(4) 2021 p.784-789

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Published

2021-06-18

How to Cite

Basu, K., Sarkar, S., Karmakar, S., Das, D., Das, C., & Sarkar, R. (2021). Role of cytokines in Granulomatous Colitis. Bangladesh Journal of Medical Science, 20(4), 784–789. https://doi.org/10.3329/bjms.v20i4.54135

Issue

Vol. 20 No. 4 (2021)

Section

Original Articles

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