Prognostic information of gastric carcinoma using Goseki system in relation to nuclear organizer region (AgNOR) and proliferating cell nuclear antigen (PCNA) expression

Authors

  • Sulekha Gosh Associate Professor, Department of Pathology, Burdwan Medical College, West Bengal
  • Tapan Kumar Ghosh Demonstrator, Department of Pathology, Burdwan Medical College, West Bengal
  • Nikhilesh Dewasi PGT, Department of Pathology, Burdwan Medical College, West Bengal
  • Krishnendu Das PGT, Department of Pathology, Burdwan Medical College, West Bengal

DOI:

https://doi.org/10.3329/bjms.v9i2.5655

Keywords:

Goseki grade, gastric carcinoma, AgNOR, PCNA

Abstract

Objective: The present study was undertaken to find out the relationship of Goseki grading system (I-IV) with existing classification of WHO, Lauren and tumour differentiation of gastric carcinoma and its prognostic information in relation to AgNOR & PCNA expression. Materials and methods: To assess the reproducibility and usefulness of Goseki grading system thirty five gastric carcinoma were selected from January 2007 to July 2009 in the department of Pathology, Burdwan Medical College in West Bengal, India and analyzed in relation to existing grading system by chi-squared testing. Mean AgNOR count & mean PCNA leveling index quantities of different tissue sections were assessed according to different classification system of gastric carcinoma and interobserver variations of all data were evaluated from Spearman Rank-order Correlation Coefficient (rs ). Results: Highly significant predictable correlation of Goseki grading system for existing classification of gastric carcinoma was obtained statistically. Increasing values of mean AgNOR count and PCNA leveling index (2.35% & 15.14%, 2.91% & 21.32%, 3.08 %& 24.76% and 3.2% & 25.12 respectively) were observed from Grade I – IV of Goseki grade. Mucin rich (3.05% & 23.22%) and tubule poor (3.14% & 24.76%) tumours higher values than mucin poor (2.71% & 19.95%) and tubule rich (2.63% & 18.23%) tumors. No significant correlations were observed in other grading system. Conclusion: Following Goseki grading system increasing expression of proliferating marker in mucin rich than mucin poor tumours and tubules poor than tubules rich tumors indicate poor prognosis and tumour behavior. Simple system may help to select patients for adjuvant therapy.

Key words: Goseki grade; gastric carcinoma; AgNOR; PCNA.

DOI: 10.3329/bjms.v9i2.5655

Bangladesh Journal of Medical Science Vol.09 No.2 Apr 2010 pp.76-86

Downloads

Download data is not yet available.
Abstract
73
PDF
77
Cover BJMS

Downloads

Published

2010-08-04

How to Cite

Gosh, S., Ghosh, T. K., Dewasi, N., & Das, K. (2010). Prognostic information of gastric carcinoma using Goseki system in relation to nuclear organizer region (AgNOR) and proliferating cell nuclear antigen (PCNA) expression. Bangladesh Journal of Medical Science, 9(2), 76–86. https://doi.org/10.3329/bjms.v9i2.5655

Issue

Vol. 9 No. 2 (2010)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.