Development of the Heart Muscle after Antenatal Ethanol Intoxication during the Neonatal Period

Authors

  • Galina Zhanaidarova Department of Morphology and Physiology, Non-Profit Joint Stock Company “Medical University of Karaganda”, Karaganda, Kazakhstan
  • Nurlan Nauryzov Department of Morphology and Physiology, Non-Profit Joint Stock Company “Medical University of Karaganda”, Karaganda, Kazakhstan
  • Kulash Nurseitova Department of Morphology and Physiology, Non-Profit Joint Stock Company “Medical University of Karaganda”, Karaganda, Kazakhstan
  • Leila Arystan Department of Family Medicine, Non-Profit Joint Stock Company “Medical University of Karaganda”, Karaganda, Kazakhstan
  • Rustam Dyussembekov Department of Neurology, Neurosurgery, Psychiatry and Rehabilitation, Non-Profit Joint Stock Company “Medical University of Karaganda”, Karaganda, Kazakhstan
  • Gulmira Turdunova Department of Obstetrics and Gynecology, Non-Profit Joint Stock Company “Medical University of Karaganda”, Karaganda, Kazakhstan
  • Sayn Zhanbyrbaeva Department of Neurology, Neurosurgery, Psychiatry and Rehabilitation, Non-Profit Joint Stock Company “Medical University of Karaganda”, Karaganda, Kazakhstan
  • Gulbanu Akhmetova Department of Morphology and Physiology, Non-Profit Joint Stock Company “Medical University of Karaganda”, Karaganda, Kazakhstan

DOI:

https://doi.org/10.3329/bjms.v21i2.58067

Keywords:

cardiac muscle; electron microscopy; fetal alcohol syndrome; neonatal period; postnatal development

Abstract

Objective: The aim of the study was to study the effect of antenatal ethanol intoxication on the postnatal development of the heart muscle during the neonatal period.

Materials and methods: The experiment was carried out on 24 pregnant female rats weighing 180-200 grams. The animals were divided into 2 groups: experimental and control. 12 animals of the experimental group were injected with a 30% ethanol solution from 6 to 21 days of gestation daily, once, endogastrically, at a dose of 5 g / kg. The animals of the control group were injected with the same volume of physiological saline.

Results and Discussion: On the 1st and 7th days after birth, the rat pups were killed by decapitation under light ether anesthesia. After determining the mass of the heart, part of the organ was studied electron microscopically, part was fixed in 10% neutral formalin, then histological preparations were prepared in accordance with standard methods. Sections were stained with hematoxylin and eosin. The nuclear-cytoplasmic ratio in cardiomyocytes, the specific density of the capillary network of the myocardium, and the specific density of cardiomyocytes were measured. The data obtained were statistically processed.

Conclusion: The study showed that antenatal ethanol intoxication has a pronounced effect on the postnatal development of the heart muscle during the neonatal period, which manifests itself at the cellular and subcellular levels. The value of the obtained results lies in the fact that for the first time ultrastructural changes in postnatal development in the neonatal period of the fetal heart muscle during prenatal ethanol intoxication are shown at the electron microscopic level.

Bangladesh Journal of Medical Science Vol. 21 No. 02 April’22 Page : 344-353

Downloads

Download data is not yet available.
Abstract
23
PDF
59

Downloads

Published

2022-02-25

How to Cite

Zhanaidarova, G. ., Nauryzov, N. ., Nurseitova, K. ., Arystan, L. ., Dyussembekov, R. ., Turdunova, G. ., Zhanbyrbaeva, S. ., & Akhmetova, G. . (2022). Development of the Heart Muscle after Antenatal Ethanol Intoxication during the Neonatal Period. Bangladesh Journal of Medical Science, 21(2), 344–353. https://doi.org/10.3329/bjms.v21i2.58067

Issue

Vol. 21 No. 2 (2022)

Section

Original Articles

License

Copyright (c) 2022 Galina Zhanaidarova, Nurlan Nauryzov, Kulash Nurseitova, Leila Arystan, Rustam Dyussembekov, Gulmira Turdunova, Sayn Zhanbyrbaeva, Gulbanu Akhmetova

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.