Genetic Polymorphism of the Angiotensin-Converting Enzyme in Bronchial Asthma

Authors

  • Mariya Marushchak Department of Functional and Laboratory Diagnostics, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine
  • Inna Krynytska Department of Functional and Laboratory Diagnostics, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine
  • Oleksandr Tokarskyy Department of Medical Biochemistry, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine
  • Mariya Koval Department of General Chemistry, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine
  • Mykhailo Demianchuk Department of Medical Prevention Disciplines and Laboratory Diagnostics, Faculty of Medicine and Pharmacy, Municipal Institution of Higher Education “Rivne Medical Academy” of Rivne Regional Council

DOI:

https://doi.org/10.3329/bjms.v21i3.59561

Keywords:

bronchial asthma; genetic factors; ACE gene polymorphism

Abstract

Background: Bronchial asthma (BA) is among the most prevalent chronic inflammatory disorders of the lung airways, and it has become clear that a combination of genetic predisposition and environmental factors plays a critical role in its pathogenesis.

Objective: The correlation of the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism and other factors with risk for bronchial asthma development was assessed.

Materials and Methods: Online literature search was conducted to identify the most relevant studies.

Results and Discussion: The ACE insertion/deletion (I/D) gene polymorphism, correlating with cellular and circulating ACE concentration, may play a critical role in BA pathogenesis and has been a focus of numerous epidemiologic studies; however, the results are currently inconclusive. The contradictions in the literature between research groups on the role of ACE alleles and genotypes can be explained by genetic variation and multifactorial causes of BA.

Conclusion: This literature review demonstrates that the ACE I/D polymorphism might be related to the risk of bronchial asthma and can become a useful tool in designing effective treatment approaches.

Bangladesh Journal of Medical Science Vol. 21 No. 03 July’22 Page: 492-501

Downloads

Download data is not yet available.
Abstract
391
PDF
497

Downloads

Published

2022-05-21

How to Cite

Marushchak, M. ., Krynytska, I. ., Tokarskyy, O. ., Koval, M. ., & Demianchuk, M. . (2022). Genetic Polymorphism of the Angiotensin-Converting Enzyme in Bronchial Asthma. Bangladesh Journal of Medical Science, 21(3), 492–501. https://doi.org/10.3329/bjms.v21i3.59561

Issue

Vol. 21 No. 3 (2022)

Section

Review Article

License

Copyright (c) 2022 Mariya Marushchak, Inna Krynytska, Oleksandr Tokarskyy, Mariya Koval, Mykhailo Demianchuk

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.