Positive correlation of serum interleukin-13 and total immunoglobulin E in bronchial asthma patients

Authors

  • Khursheed Javaid Department of Immunology, University of Health Sciences, Lahore, Pakistan
  • Ahmad Nadeem Department of Medicine, Ittefaq Hospital (Trust) Lahore, Pakistan
  • Saleem u Zaman Adhami Department of Medicine, Shalamar Hospital Lahore, Pakistan
  • Malik Asif Hussain Department of Pathology, College of Medicine, University of Hail, Hail, KSA
  • Romeeza Tahir Department of Immunology, University of Health Sciences, Lahore, Pakistan
  • Faheem Shahzad Department of Immunology, University of Health Sciences, Lahore, Pakistan
  • Shah Jahan Department of Immunology, University of Health Sciences, Lahore, Pakistan
  • Nadeem Afzal Department of Immunology, University of Health Sciences, Lahore, Pakistan

DOI:

https://doi.org/10.3329/bjms.v21i3.59573

Keywords:

Allergy; bronchial asthma; IgE; IL-13

Abstract

Background: Asthma is a chronic inflammation of airways, associated with hyper-responsiveness of the bronchial tree, resulting in reiterated attacks of cough, wheezing, chest tightness, and breathlessness. Aapproximately 4 Pakistani adults out of 100 persons have been reported to suffer from asthma in year 2002-03.This study focuses on determining interleukin-13 (IL-13) and immunoglobulin E (IgE) in asthma patients and healthy subjects.

Settings and Design: Methods and Material: The study assessed the level and correlation of IL-13 and IgE in bronchial asthma patients. Fifty bronchial asthma patients with allergy history and thirty healthy individuals were included. The patients were selected from Gulab Devi Chest Hospital, Lahore, Pakistan. Total serum IgE and IL-13 were determined by ELISA technique.SPSS (Version 20.0) software was used for statistical analysis. Kolmogorov-Smirnov, Shapiro-Wilk test, Student t-test and Mann-Whitney test have been used in analysis.

Results: The mean (±SD) values of IL-13 concentration (pg/ml) in asthmatics and controls (healthy) were 1574 (± 409) and 390 (± 23). Moreover, median (IQR) value for both groups were 1415.8 (1398-1554) and 394.3 (384.3- 404.3), respectively.

Conclusions: To sum up, we have found that bronchial asthma patients had significantly increased level of total serum IgE and IL-13 and we found a positive correlation between these parameters.

Bangladesh Journal of Medical Science Vol. 21 No. 03 July’22 Page: 596-600

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Published

2022-05-21

How to Cite

Javaid, K. ., Nadeem, A. ., Adhami, S. u Z., Hussain, M. A., Tahir, R., Shahzad, F., Jahan, S., & Afzal , N. (2022). Positive correlation of serum interleukin-13 and total immunoglobulin E in bronchial asthma patients. Bangladesh Journal of Medical Science, 21(3), 596–600. https://doi.org/10.3329/bjms.v21i3.59573

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Original Articles