Angiotensin converting enzyme 2 in the gastrointestinal tract: binding with coronavirus and its consequences

Authors

  • Jesmine Khan Faculty of Medicine, Sungai Buloh Campus, Universiti Teknologi MARA, Jalan Hospital, Selangor 47000, Malaysia
  • Wan Nor I’zzah Wan Mohamad Zain Faculty of Medicine, Sungai Buloh Campus, Universiti Teknologi MARA, Jalan Hospital, Selangor 47000, Malaysia
  • Mohammed Nasimul Islam Faculty of Medicine, Sungai Buloh Campus, Universiti Teknologi MARA, Jalan Hospital, Selangor 47000, Malaysia

DOI:

https://doi.org/10.3329/bjms.v21i4.60276

Keywords:

ACE2; corona virus;gut microbiota; intestinal permeability; inflammatory bowel disease

Abstract

Introduction: Angiotensin converting enzyme 2 (ACE2) is expressed in several cell types in the body including the gastrointestinal (GI) epithelium.

Objective:To provide an overview of the normal distribution of ACE2 in the GI tract, altered ACE2 expression notably in coronavirus infection and its consequences.

Materials and Methods: Pubmed and google scholar were searched using the key words ACE2 paired with GI tract, intestinal permeabilty, gut microbiota, inflammatory bowel disease.

Results and Discussion: ACE2 is highly expressed in the ileum and colon in human being as well as in rodents. In this current situation of COVID-19 pandemic, downregulation of ACE2 has been reported due to internalization of the ACE2-virus complex within the cells. Although researches are still in infancy in this topic, altered luminal microbiota, increased intestinal permeability, higher level of inflammatory markers and deficient nutrient transport has been reported due to altered ACE2 expression.

Conclusion:Altered expression of ACE2 has the possibility to hamper normal physiological function of the GI tract and might affect GI disease progression and prognosis.

Bangladesh Journal of Medical Science Vol. 21 No. 04 October’22 Page : 808-812

Downloads

Download data is not yet available.
Abstract
26
PDF
63

Downloads

Published

2022-09-11

How to Cite

Khan, J. ., Mohamad Zain, W. N. I. W. ., & Islam, M. N. . (2022). Angiotensin converting enzyme 2 in the gastrointestinal tract: binding with coronavirus and its consequences. Bangladesh Journal of Medical Science, 21(4), 808–812. https://doi.org/10.3329/bjms.v21i4.60276

Issue

Vol. 21 No. 4 (2022)

Section

Original Articles

License

Copyright (c) 2022 Jesmine Khan, Wan NorI’zzah Wan Mohamad Zain, Mohammed Nasimul Islam

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.