A hospital based study of Hereditary Hemolytic Anaemias in Davanagere district of Karnataka, India

Authors

  • BP Preethi Assistant professor, MD Biochemistry, J.J.M. Medical College, Davanagere, Karnataka
  • K Monika post graduate student, MD Biochemistry, J.J.M. Medical College, Davanagere, Karnataka
  • DS Maitreyee post graduate student, MD Biochemistry, J.J.M. Medical College, Davanagere, Karnataka
  • K Rashmi post graduate student, MD Pathology, J.J.M. Medical College, Davanagere, Karnataka

DOI:

https://doi.org/10.3329/bjms.v9i3.6471

Keywords:

hereditary hemolytic anaemia, clinoco-hematological study, hemoglobin electrophoresis

Abstract

Background: Hereditary hemolytic anaemias constitute important cause of mortality and morbidity in developing countries next only to infection and malnutrition.These group of anaemias have various clinical presentations starting from their age of onset of symptoms, failure to thrive, anaemia, prostration, jaundice, splenomegaly, cholelithiasis, cardiomegaly, congestive cardiac failure, severe life threatening infections and chronic disabilities leading to distress in the families.
Methodology: An analysis of 40 cases of hereditary hemolytic anaemia in the age group of 2 months to 12 years was done in the present study. On the basis of clinical presentations, physical findings, routine hematological investigations and hemoglobin electrophoresis pattern in hemoglobin defects were carried out to identify the type of hemolytic anaemias.
Results: This clinocohematological study of hereditary hemolytic anaemia showed membrane defects- Hereditary spherocytosis in 4 cases (10%). The remaining 36 cases were having diseases affecting hemoglobin molecule which included Sickle cell anaemia-5 cases (12.5%), Sickle cell trait- 1 case (2.5%), Sickle cell/β thalassemia-1 case (2.5%), β thalassemia major- 23 cases (57.5%) and β thalassemia trait 6 cases(15%). Hereditary hemolytic anaemia with enzyme defects were not observed in this study. Majority of these cases presented with progressive pallor and hepatosplenomegaly. Peripheral blood smear examination showed microcytic hypochromic anaemia (87.5%) in majority of the cases. All cases were associated with reticulocytosis. Hemoglobin electrophoresis confirmed the diagnosis.
Conclusion: Inspite of advanced diagnostic inestigations, the basic hematological investigation remains first panel or step towards the approach to diagnose hereditary hemolytic anaemia and hemoglobin electrophoresis will help in confirming the diagnosis.

Keywords: hereditary hemolytic anaemia; clinoco-hematological study; hemoglobin electrophoresis

DOI: 10.3329/bjms.v9i3.6471

Bangladesh Journal of Medical Science Vol.09 No.3 July 2010, pp.154-160

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How to Cite

Preethi, B., Monika, K., Maitreyee, D., & Rashmi, K. (2010). A hospital based study of Hereditary Hemolytic Anaemias in Davanagere district of Karnataka, India. Bangladesh Journal of Medical Science, 9(3), 154–160. https://doi.org/10.3329/bjms.v9i3.6471

Issue

Vol. 9 No. 3 (2010)

Section

Original Articles

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