Molecular and haematological characterization of deletional alpha thalassemia in northeastern Malaysia

Authors

  • Rosnah Bahar Hematology department, School of Medical Sciences, Health Campus, UniversitiSains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
  • Salman Mohd Sahid Department of Hematology, Hospital Tengku Ampuan Afzan, Jalan Tanah Putih, Kuantan, Pahang, Malaysia
  • Marini Ramli Hematology department, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
  • Noor Haslina Mohd Noor Hematology department, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
  • Shafini Mohamed Yusoff Hematology department, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
  • Samilawati Mohd Arifin Hematology department, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
  • Zefarina Zulkafli School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia

DOI:

https://doi.org/10.3329/bjms.v22i2.65005

Keywords:

deletional alpha thalassemia;hematological parameters; screening tool; molecular

Abstract

Background: Alpha (α) thalassemia is an inherited condition that often cause public health problem in Malaysia. Thalassemia screening program plays extremely important roles for early detection. Therefore, it is important to accurately characterized molecular and hematologic parameters to determine the carrier genotype and prevent thalassaemia major or intermedia offspring.

Objective: The objective of this study is to detect α-globin gene deletions and evaluate the haematological parameters among deletional α thalassemia patients in Hospital Universiti Sains Malaysia, Northeastern Malaysia.

Result: 71 (33.2%) out of of 214 samples in this study, were detected with α thalassaemia deletional type. South-East Asian (SEA) (50.7%) was most common type α deletional thalassaemia detected. There was a significant difference between the median of Hb, MCV and MCH level of patients with and without α deletion.

Conclusion: This study highlighted the importance of hematological parameter as well as Hb analysis to be used as a guide before proceed with molecular method in establishing a definitive diagnosis for proper management.

Bangladesh Journal of Medical Science Vol. 22 No. 02 April’23 Page : 410-415

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Published

2023-04-11

How to Cite

Bahar, R. ., Sahid, S. M. ., Ramli, M. ., Noor, N. H. M. ., Yusoff, S. M. ., Arifin, S. M. ., & Zulkafli, Z. . (2023). Molecular and haematological characterization of deletional alpha thalassemia in northeastern Malaysia. Bangladesh Journal of Medical Science, 22(2), 410–415. https://doi.org/10.3329/bjms.v22i2.65005

Issue

Vol. 22 No. 2 (2023)

Section

Original Articles

License

Copyright (c) 2023 Rosnah Bahar, Salman Mohd Sahid, Marini Ramli, Noor Haslina Mohd Noor, Shafini Mohamed Yusoff, Samilawati Mohd Arifin, Zefarina Zulkafli

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