Moringa Oleifera Extract Decreases Interleukin 6 Levels and Disease Activity in Rheumatoid Arthritis Patients

Authors

  • Nurhasan Agung Prabowo Faculty of Medicine, Universitas Sebelas Maret, Ir Sutami street No 36, Kentingan, Jebres, Surakarta, Indonesia, 57126
  • Arief Nurudhin Faculty of Medicine, Universitas Sebelas Maret, Ir Sutami street No 36, Kentingan, Jebres, Surakarta, Indonesia, 57126
  • Yulyani Werdiningsih Faculty of Medicine, Universitas Sebelas Maret, Ir Sutami street No 36, Kentingan, Jebres, Surakarta, Indonesia, 57126
  • Dikha Dwi Putra Faculty of Medicine, Universitas Sebelas Maret, Ir Sutami street No 36, Kentingan, Jebres, Surakarta, Indonesia, 57126
  • Desy Puspa Putri Faculty of Medicine, Universitas Sebelas Maret, Ir Sutami street No 36, Kentingan, Jebres, Surakarta, Indonesia, 57126
  • Retno Widyastuti Faculty of Medicine, Universitas Islam Sultan Agung, Kaligawe Raya Street, Terboyo Kulon, Genuk, Semarang, Jawa Tengah 50112

DOI:

https://doi.org/10.3329/bjms.v22i2.65006

Keywords:

Moringa oleifera; Interleukin 6; SDAI Score; Rheumatoid Arthritis

Abstract

Moringa oleifera (MO) has anti-inflammatory, anti-arthritis, and immunosuppressant effects in Rheumatoid Arthritis (RA). This study aims to determine the effect of moringa oleifera extract on interleukin 6 levels and disease activity in RA. This research, with 30 patients, was divided into two groups: the intervention and the placebo. The intervention group received 40.50 mg/kg BW/day of Moringa oleifera extract for one month. IL-6 levels and SDAI scores were measured before and after the treatment. Paired t-test showed that IL-6 levels (p=0.070) and SDAI Scores (p=0.142) before and after MO administration for the control group were not significantly different (p> 0.05). Paired t-test IL-6 (p=0.001) and SDAI Scores (p=0.001) before and after giving MO to the treatment group decreased significantly (p <0.05). Independent t-test shows that the two changes, Delta-IL6 (p=0,008) and Delta-SDAI (p=0,017), are significantly different (p<0.05). Moringa Oleifera Extract decreases IL-6 Levels and SDAI Scores in RA Patients.

Bangladesh Journal of Medical Science Vol. 22 No. 02 April’23 Page : 416-421

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Published

2023-04-11

How to Cite

Prabowo, N. A. ., Nurudhin, A. ., Werdiningsih, Y. ., Putra, D. D. ., Putri, D. P. ., & Widyastuti, R. . (2023). Moringa Oleifera Extract Decreases Interleukin 6 Levels and Disease Activity in Rheumatoid Arthritis Patients. Bangladesh Journal of Medical Science, 22(2), 416–421. https://doi.org/10.3329/bjms.v22i2.65006

Issue

Vol. 22 No. 2 (2023)

Section

Original Articles

License

Copyright (c) 2023 Nurhasan Agung Prabowo, Arief Nurudhin, Yulyani Werdiningsih, Dikha Dwi Putra, Desy Puspa Putri, Retno Widyastuti

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