The Effect of Snail Mucus (Achatina Fulica) Toward The Activity and Chronicity Indices of Renal Histology in Pristane-Induced Lupus Nephritis Mice Model

Authors

  • Arief Nurudhin Internal Medicine Departement, Faculty of Medicine, Universitas Sebelas Maret
  • Nurhasan Agung Prabowo Internal Medicine Departement, Universitas Sebelas Maret Hospital, Sukoharjo, Central Java, Indonesia
  • Yulyani Werdiningsih Internal Medicine Departement, Moewardi General Hospital, Surakarta, Central Java, Indonesia
  • Fatichati Budiningsih Internal Medicine Departement, Moewardi General Hospital, Surakarta, Central Java, Indonesia
  • Tiara Maharani Internal Medicine Departement, Moewardi General Hospital, Surakarta, Central Java, Indonesia
  • Agung Karyawinara Internal Medicine Departement, Moewardi General Hospital, Surakarta, Central Java, Indonesia
  • Retno Widyastuti Internal Medicine Departement, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang, Central Java, Indonesia

DOI:

https://doi.org/10.3329/bjms.v22i3.65320

Keywords:

Achatina fulica; activity index; chronicity index; lupus nephritis; snail mucus

Abstract

Background: Snail mucus (Achatina Fulica) has been known to contain heparan sulfate, and acharan sulfate, a glycosaminoglycan with anti-inflammatory properties and might repair the injured glomeruli.

Aim: This study aims to find the effect of snail mucus on activity and chronicity indices of renal histology in a pristane-induced lupus nephritis mice model.

Method: This was an experimental study with a post-test-only control group design using 42 mice strains Balb/C. Mice were randomized into six groups: control, lupus nephritis, methylprednisolone, snail mucus 0.5 ccs, snail mucus 0,5 cc and methylprednisolone, and snail mucus one cc and methylprednisolone group.

Result: Snail mucus significantly affected the activity index (p = 0.001). The lowest activity index was shown by snail mucus one cc and methylprednisolone group. While the chronicity index was not significantly affected by the snail mucus with p = 0.195. Snail mucus decreases the activity index of renal histology in the pristane-induced lupus nephritis mice model but not the chronicity index.

Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 515-520

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Published

2023-06-16

How to Cite

Nurudhin, A. ., Prabowo, N. A., Werdiningsih, Y., Budiningsih, F. ., Maharani, T., Karyawinara, A., & Widyastuti, R. (2023). The Effect of Snail Mucus (Achatina Fulica) Toward The Activity and Chronicity Indices of Renal Histology in Pristane-Induced Lupus Nephritis Mice Model. Bangladesh Journal of Medical Science, 22(3), 515–520. https://doi.org/10.3329/bjms.v22i3.65320

Issue

Vol. 22 No. 3 (2023)

Section

Original Articles

License

Copyright (c) 2023 Arief Nurudhin, Nurhasan Agung Prabowo, Yulyani Werdiningsih, Fatichati Budiningsih, Tiara Maharani, Agung Karyawinara, Retno Widyastuti

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