Investigation of the relationship between DNA methylation of PTH, ESRRA, FSHR and obesity: A single center study

Authors

  • Huseyin Cagsin Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Near East University, Nicosia, Cyprus
  • Eda Becer Department of Biochemistry, Faculty of Pharmacy, Near East University, Near East Boulevard, ZIP. 99138 Nicosia, Cyprus
  • Rasime Kalkan Department of Medical Genetics, Faculty of Medicine, Cyprus Health and Social Sciences University, Morphou, Cyprus

DOI:

https://doi.org/10.3329/bjms.v22i3.65336

Keywords:

Obesity; Epigenetics; Methylation; FSHR; PTH; ESRRA

Abstract

Background: Obesity is a multifactorial disorder that is an important predisposing factor for a number of disorders. Genetic and epigenetic variations play important roles during the development of obesity.

Method: DNA methylation is the most studied as one of the epigenetic modifications and is directly related to gene expression. Here, the methylation status of FSHR, PTH and ESRRA genes were investigated in obese patients to discover novel associations between DNA methylation and obesity phenotype. A total of 69 patients with obesity and 76 patients without obesity were enrolled in this study. DNA methylation in FSHR, PTH and ESRRA genes was analyzed.

Result: There is a statistically significant association between the methylation status of ESRRA and fasting glucose (P=0.04) and BMI and methylation of the PTH gene (P=0.036) in obese subjects. In non-obese subjects, a statistically significant association was detected between adiponectin, resistin levels and FSHR methylation status. It is concluded that the methylation status of FSHR, PTH and ESRRA genes play an important role in obesity phenotype, adiponectin and resistin levels. These genes had previously been associated with obesity-related variables, but their methylation status was not highlighted.

Conclusion: Our study will shed light on resolving the epigenetic contributions toward the development of obesity. Studies in the field of epigenetics will help discover predisposition markers for obesity. Based on the literature this was the first study that shows the interactions between FSHR, PTH and ESRRA methylation and obesity.

Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 623-631

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Published

2023-06-16

How to Cite

Cagsin, H. ., Becer, E., & Kalkan, R. (2023). Investigation of the relationship between DNA methylation of PTH, ESRRA, FSHR and obesity: A single center study. Bangladesh Journal of Medical Science, 22(3), 623–631. https://doi.org/10.3329/bjms.v22i3.65336

Issue

Vol. 22 No. 3 (2023)

Section

Original Articles

License

Copyright (c) 2023 Huseyin Cagsin, Eda Becer, Rasime Kalkan

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