Involvement of ACE2 in the intestinal transport of amino acids: Possible health and nutritional consequences in altered expression

Authors

  • Jesmine Khan Department of Biochemistry and Molecular Medicine, Faculty of Medicine
  • Wan Nor I’zzah Wan Mohamad Zain Department of Biochemistry and Molecular Medicine
  • Mohammed Nasimul Islam Department of Forensic Pathology.

DOI:

https://doi.org/10.3329/bjms.v22i4.67115

Keywords:

ACE2, B0AT1; SIT1; intestine; gut, amino acid transport; amino acid absorption; nutrition

Abstract

Background:Absorption of neutral amino acids across the intestinal cells is mediated by the broad neutral amino acid transporter B0AT1. Intestinal expression of B0AT1 depends on the coexistence with the membrane-attached angiotensin-converting enzyme 2 (ACE2) which binds to the B0AT1 or the sodium-dependent imino-acid transporter 1 (SIT1) in the intestinal epithelial cells.

Objectives:The objective of this article is to provide an overview of the involvement of ACE2 in the transport of amino acids from the intestinal lumen and possible harmful effects on health and nutrition due to altered ACE2 expression.

Methods: PubMed, Scopus, and Google Scholar were searched using the keywords ACE2 paired with intestinal and gut B0AT1, SIT1, amino acid transport or absorption, health, and nutrition. Expression of B0AT1 in the intestine was completely absent in ACE2 knockout mice. Lack of ACE2 and B0AT1 expression lead to low plasma and muscle tryptophan, niacin deficiency, decreased intestinal antimicrobial peptide, and increased susceptibility to inflammatory bowel disease in animal models.

Results: Expression of ACE2 in the small intestine and its association with amino acid transporters play a crucial role in the absorption of amino acids, maintenance of structural and functional gut integrity and overall health and nutrition status of an individual.

Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 729-733

Downloads

Download data is not yet available.
Abstract
42
PDF
74

Downloads

Published

2023-09-07

How to Cite

Khan, J. ., Zain, W. N. I. W. M. ., & Islam, M. N. . (2023). Involvement of ACE2 in the intestinal transport of amino acids: Possible health and nutritional consequences in altered expression. Bangladesh Journal of Medical Science, 22(4), 729–733. https://doi.org/10.3329/bjms.v22i4.67115

Issue

Vol. 22 No. 4 (2023)

Section

Review Article

License

Copyright (c) 2023 Jesmine Khan, Wan Nor I’zzah Wan Mohamad Zain, Mohammed NasimuI Islam

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.