Neuron-specific enolase level research in children with COVID-19
DOI:
https://doi.org/10.3329/bjms.v23i2.67164Keywords:
COVID-19, neuromarker, NSE, children, nervous system, laboratory-instrumental diagnostics, SARS-СoV-2Abstract
Introduction COVID-19 is a relevant issue for scientists around the world. Considering the development of numerous complications due to COVID-19, the search for diagnostic approaches for the timely detection of probable lesions of the nervous system is urgent.
Objectives was to determine the diagnostic and prognostic value of the NSE marker in children with COVID-19 regarding the complicated course and symptoms of nervous system damage.
Materials and methods We conducted a cohort, observational, retrospective study involving 88 children aged 1 month to 18 years with laboratory-confirmed COVID-19 by PCR. Blood serum was collected for the study to assess the level of the neurobiomarker NSE by enzyme immunoassay. We divided patients into two cohorts according to the course of the disease - the main one, which included 42 patients with a complicated course of COVID-19, and a control group - 46 patients with an uncomplicated course of the disease. The study protocol was approved by the Local Ethics Committee of the hospital. Results: In the patients of the control group, NSE was observed at the level of 12.1±1.2 μg/l, while in the children of the main one, the indicator reached 16.9±1.5 μg/l (p=0.087). Increase in the level of NSE above 15 μg/L associated with a significant increase in the risk of the appearance of clinical symptoms of damage to the nervous system and a complicated course in children with COVID-19 (p<0.05). We noted a tendency towards an increase in NSE with increased ESR indicators >10mm/h (p<0.1), a decrease in PTI <85% (p=0,03) and an increase in D-dimer >2.5mg/l (p<0.1).
Conclusions We found the diagnostic and prognostic value of the NSE marker in children with COVID-19 regarding the complicated course and symptoms of nervous system damage.
Bangladesh Journal of Medical Science Vol. 23 No. 02 April’24 Page : 388-397
Downloads
15
25
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Iryna Seriakova, Sergiy Kramarov , Vitalii Yevtushenko , Nataliia Kyrytsia , Valerii Shadrin , Oleksandr Voronov , Vitalii Byk , Inna Grynevych, Hanna Zaslavska, Antonina Zlobynets
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:
- Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.
Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.- Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.
