Bibliometric analysis and network visualization on Tuberous Sclerosis Complex

Authors

  • Ninie Nadia Zulkipli School of Biomedicine, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, 21300 Kuala Nerus, Terengganu, Malaysia.
  • Idris Long School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia.
  • Habibah A Wahab School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Pulau Pinang, Malaysia.
  • Teguh Haryo Sasongko School of Medicine, and Institute for Research, Development and Innovation, International Medical University, 57000 Kuala Lumpur, Malaysia.
  • Asma Hayati Ahmad School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia.
  • Zahiruddin Othman School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia.
  • Aidi Ahmi Tunku Puteri Intan Safinaz School of Accountancy, Universiti Utara Malaysia 06010 UUM Sintok, Kedah, Malaysia.
  • Rahimah Zakaria School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia.

DOI:

https://doi.org/10.3329/bjms.v23i1.70664

Keywords:

TSC, mTOR; Scopus; bibliometrix R; VOSviewer

Abstract

Background: Tuberous sclerosis complex (TSC) is a rare autosomal dominant multisystem disease resulting from hyperactivation of the mammalian target of rapamycin (mTOR) signaling pathway. This study aimed to measure the quantitative impact of publications in TSC.

Materials and methods: We analysed TSC literature obtained from the Scopus database using Bibliometrix R Package and VOSviewer software. Annual publication trends, most productive and collaborative authors/institutions/ countries, most cited articles, most popular journals and author’s keywords were presented using standard bibliometric indicators.

Results and discussion: A total of 5375 documents on TSC were published from 1960 to December 2020, with an increasing trend. The three primary contributing writers were Curatolo P, Kwiatkowski DJ, and Thiele EA, with the United States and its institutions being the largest contributor. The research identified two of the most referenced papers as TSC’s seminal pieces. The top journals that published TSC research were medical journals, namely Journal of Child Neurology, Epilepsia, and Pediatric Neurology. mTOR inhibitor, everolimus, sirolimus, mTORC1, mTOR pathway, autophagy, inflammation, infant, intellectual disability, white matter, TSC-associated neuropsychiatric disorders, TOSCA and quality of life were relatively newer author’s keywords and may indicate the future research hotspots in TSC research.

Conclusion: Over the last few decades, TSC research has grown in importance, particularly in the field of clinical medicine. Therapeutic components targeting TSC-related pathways, the utilisation of TSC as disease models and long-term safety studies will be future research areas.

Bangladesh Journal of Medical Science Vol. 23 No. 01 January’24 Page : 18-28

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Published

2024-01-02

How to Cite

Zulkipli, N. N. ., Long, I. ., Wahab, H. A. ., Sasongko, T. H. ., Ahmad, A. H. ., Othman, Z. ., Ahmi, A. ., & Zakaria, R. . (2024). Bibliometric analysis and network visualization on Tuberous Sclerosis Complex. Bangladesh Journal of Medical Science, 23(1), 18–28. https://doi.org/10.3329/bjms.v23i1.70664

Issue

Vol. 23 No. 1 (2024)

Section

Review Article

License

Copyright (c) 2024 Ninie Nadia Zulkipli, Idris Long, Habibah A Wahab, Teguh Haryo Sasongko, Asma Hayati Ahmad, Zahiruddin Othman, Aidi Ahmi, Rahimah Zakaria

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