Serum lipid profile among pediatric folk with idiopathic nephrotic syndrome: An Observational Study

Authors

  • Partha Kumar Chaudhuri Department of Pediatrics, Rajendra Institute of Medical Sciences, Ranchi University, India.
  • Akanksha Kumari Department of Pediatrics, Rajendra Institute of Medical Sciences, Ranchi University, India.
  • Ananya Ghosh Department of Pediatrics, Shaheed Nirmal Mahto Medical College, Dhanbad, India.
  • Basant Kumar Department of Pediatrics, Rajendra Institute of Medical Sciences, Ranchi University, India.
  • Pankaj Kumar Department of Pediatrics, Rajendra Institute of Medical Sciences, Ranchi University, India.
  • Shreya Gajjar Department of Periodontology, Karnavati School Dentistry, Uvarsad, Gandhinagar, India.
  • Md Ahsanul Haq Infectious Diseases Division, icddr, b, Mohakhali, Dhaka-1212, Bangladesh
  • Susmita Sinha Department of Physiology, Khulna City Medical College and Hospital, 33 KDA Avenue, Hotel Royal Crossing, Khulna Sadar, Khulna 9100, Bangladesh.
  • Mainul Haque Unit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kem Perdana Sungai Besi, 57000 Kuala Lumpur, Malaysia, Department of Scientific Research Center (KSRC) Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat-382422. India.
  • Santosh Kumar Department of Periodontology, Karnavati School Dentistry, Uvarsad, Gandhinagar, India.

DOI:

https://doi.org/10.3329/bjms.v23i1.70671

Keywords:

Hyperlipidemia, Frequent Relapse Nephrotic Syndrome, Infrequent Relapse Nephrotic Syndrome, Dyslipidemia

Abstract

Introduction: The most familiar kidney disease in children is nephrotic syndrome (NS), associated with dyslipidemia and causes various cardiovascular complications. Persistent hyperlipidemia can further raise difficulties of NS and relapse cases. Earlier diagnosis and appropriate intervention increase the possibility of saving other vital organs.

Methods: An observational study was conducted with 85 children aged 2-15 years with a history of NS. The study group was divided into first NS and second-episode relapse cases. They were further subgrouped into Frequent Relapse NS (FRNS) and Infrequent Relapse NS (IFRNS). Fasting lipid profiles were performed among active sufferers with a follow-up after 4 weeks.

Results: The male-to-female ratio was 1.93:1. In the first episode of NS, all lipid parameters were high in the acute phase and returned to normal during remission. In relapse cases, lipid parameters were significantly higher even in remission. Serum triglyceride and very low-density lipoprotein were significantly more elevated in the FRNS group than in the IFRNS. Low-density lipoprotein was increased considerably in FRNS. Mean high-density lipoprotein was also significantly lower in the FRNS group than in the IFRNS.

Conclusion: Persistent hyperlipidemia is most typical among FRNS. Hyperlipidemia management is urgent to prevent among pediatric NS.

Bangladesh Journal of Medical Science Vol. 23 No. 01 January’24 Page : 39-46

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Published

2024-01-02

How to Cite

Chaudhuri, P. K. ., Kumari, A. ., Ghosh, A. ., Kumar, B. ., Kumar, P. ., Gajjar, S. ., Haq, M. A. ., Sinha, S. ., Haque, M. ., & Kumar, S. . (2024). Serum lipid profile among pediatric folk with idiopathic nephrotic syndrome: An Observational Study. Bangladesh Journal of Medical Science, 23(1), 39–46. https://doi.org/10.3329/bjms.v23i1.70671

Issue

Vol. 23 No. 1 (2024)

Section

Original Articles

License

Copyright (c) 2024 Partha Kumar Chaudhuri, Akanksha Kumari, Ananya Ghosh, Basant Kumar, Pankaj Kumar, Shreya Gajjar, Md Ahsanul Haq, Susmita Sinha, Mainul Haque, Santosh Kumar

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