Determination of cytokines for assessment of inflammatory status at genital endometriosis

Authors

  • Leila Appazova Department of Obstetrics, gynecology and perinatology, NJSC “Karaganda Medical University”, Karaganda, Kazakhstan
  • Lyudmila Akhmaltdinova Collective Use Laboratory of the Research Center, NJSC “Karaganda Medical University”, Karaganda, Kazakhstan
  • Yasminur Turdybekova Department of Obstetrics, gynecology and perinatology, NJSC “Karaganda Medical University”, Karaganda, Kazakhstan
  • Irina Kopobayeva Department of Obstetrics, gynecology and perinatology, NJSC “Karaganda Medical University”, Karaganda, Kazakhstan
  • Zhanna Amirbekova Department of Obstetrics, gynecology and perinatology, NJSC “Karaganda Medical University”, Karaganda, Kazakhstan

DOI:

https://doi.org/10.3329/bjms.v23i1.70697

Keywords:

endometriosis; IL-6; IL-8; IL-18; TNF; cytokines

Abstract

Objective: The Aim of the research was to study the profile of serum cytokines in patients with genital endometriosis, as well as to evaluate the sensitivity and specificity of any single cytokine or combination of cytokines in predicting the inflammatory status in endometriosis.

Material and methods: The study included 48 patients. They were divided into two groups: I group (experimental) – 28 women with genital endometriosis, II group (control) - 20 healthy non-pregnant women. For the determination of serum biomarkers (IL-6, IL-8, IL-18, TNF-α, MIF) the multiplex immunofluorescence method with XMap technology was used.

Results: There were no statistical differences in IL-18 and MIF levels between the studied groups (p = 0.630 and p = 0.421). However, serum levels of IL-6, IL-8, TNF-α were significantly different (respectively, p = 0.037, p < 0.001, p < 0.001). In women with endometriosis the levels of IL-8 and TNF-α were increased 5 times, and level of IL-6 was increased 3 times. The diagnostic significance of IL-6, IL-8 and TNF-α levels for predicting genital endometriosis was 75.0% and 60.0%; 100.0% and 90.0%; 92.9% and 85.0%, respectively.

Conclusions: The levels of IL-6, IL-8, and TNF-α were significantly higher in patients with genital endometriosis. The diagnostic significance of IL-6, IL-8 and TNF-α levels for predicting genital endometriosis was also established with the determination of the sensitivity and specificity of the model.

Bangladesh Journal of Medical Science Vol. 23 No. 01 January’24 Page : 121-129

Downloads

Download data is not yet available.
Abstract
152
PDF
227

Downloads

Published

2024-01-01

How to Cite

Appazova, L. ., Akhmaltdinova, L. ., Turdybekova, Y. ., Kopobayeva, I. ., & Amirbekova, Z. . (2024). Determination of cytokines for assessment of inflammatory status at genital endometriosis. Bangladesh Journal of Medical Science, 23(1), 121–129. https://doi.org/10.3329/bjms.v23i1.70697

Issue

Vol. 23 No. 1 (2024)

Section

Original Articles

License

Copyright (c) 2024 Leila Appazova, Lyudmila Akhmaltdinova, Yasminur Turdybekova, Irina Kopobayeva, Zhanna Amirbekova

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.