Hypomethylation of Sonic hedgehog in colorectal cancer

Authors

  • Maheera Teli Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar-190011.
  • Madiha Niyaz Senior Resident, Ph.D, Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar-190011.
  • Gowhar Rashid Assistant Professor, Department of Medical Laboratory Technology, Amity Medical School, Amity University Haryana, 122413
  • Ishrat Parveiz Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar-190011.
  • Rauf A Wani Department of General and Minimal Invasive Surgery, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar- 190011.
  • Syed Mudassar Professor & Head Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar-190011.

DOI:

https://doi.org/10.3329/bjms.v23i1.70719

Keywords:

Hypomethylation; Sonic Hedgehog; Methylation specific PCR; Colorectal Cancer

Abstract

Background: Past research has demonstrated that a changed Sonic Hedgehog (SHH) pattern contributes to the development of colorectal cancer. This study’s objective was to determine whether the SHH gene’s promoter hypomethylation might be used to predict the likelihood of developing colorectal cancer.

Methods: For the current investigation, 50 newly diagnosed and untreated colorectal cancer patients’ tumor samples and surrounding non-tumor tissues were gathered. SHH methylation was determined by methylation-specific PCR (MSP) and results correlated with several studied clinicopathological parameters.

Results: Our results showed that SHH methylation levels are significantly present in normal tissues as compared to tumor tissues.

Conclusion: We conclude SHH promoter is hypomethylated in colorectal cancers which may have an effect driving normal colon and rectum cells to cancer.

Bangladesh Journal of Medical Science Vol. 23 No. 01 January’24 Page : 200-206

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Published

2024-01-01

How to Cite

Teli, M. ., Niyaz, M. ., Rashid, G. ., Parveiz, I. ., Wani, R. A. ., & Mudassar, S. . (2024). Hypomethylation of Sonic hedgehog in colorectal cancer. Bangladesh Journal of Medical Science, 23(1), 200–206. https://doi.org/10.3329/bjms.v23i1.70719

Issue

Vol. 23 No. 1 (2024)

Section

Original Articles

License

Copyright (c) 2024 Maheera Teli, Madiha Niyaz, Gowhar Rashid, Ishrat Parveiz, Rauf A Wani, Syed Mudassar

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