Patient with a rare weaker subgroup-A exhibiting ABO discrepancy: a case report

Authors

  • Rabeya Yousuf Blood Bank Unit, Department of Diagnostic Laboratory Services, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
  • Nurasyikin Yusof Blood Bank Unit, Departments of Pathology & Department of Diagnostic Laboratory Services. Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
  • Nur Afifah Suhemi Blood Bank Unit, Department of Diagnostic Laboratory Services, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
  • Nor Fadzliana Abdullah Thalith Blood Bank Unit, Department of Diagnostic Laboratory Services, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
  • Suria Abdul Aziz Blood Bank Unit, Departments of Pathology & Department of Diagnostic Laboratory Services. Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia

DOI:

https://doi.org/10.3329/bjms.v23i2.72199

Keywords:

ABO grouping; weaker subgroup A; mixed-field reaction; ABO discrepancy

Abstract

Weaker subgroups have the potential to cause problems in the immunohaematological testing in the blood banks. We report here a case of rare weaker subgroup A, detected during the usual ABO grouping. A 49-year-old lady exhibited a discrepancy in the forward and reverse groupings. In forward-grouping, there was a mixedfield reaction with anti-A and anti-A,B while there was no reaction with anti-B. The reverse grouping showed no reaction with the A1 and A2 cells, but the reaction with B-cell was 4+. Further tests were performed and revealed a weaker subgroup of A. It is crucial to properly investigate and resolve any discrepancy in ABO grouping before commencing transfusion to avoid any wrong blood transfusion. This case report may assist others in resolving the ABO blood group discrepancies.

Bangladesh Journal of Medical Science Vol. 23 No. 02 April’24 Page : 546-550

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Published

2024-03-27

How to Cite

Yousuf, R., Yusof, N. ., Suhemi, N. A., Abdullah Thalith, N. F., & Aziz, S. A. . (2024). Patient with a rare weaker subgroup-A exhibiting ABO discrepancy: a case report. Bangladesh Journal of Medical Science, 23(2), 546–550. https://doi.org/10.3329/bjms.v23i2.72199

Issue

Vol. 23 No. 2 (2024)

Section

Case Reports

License

Copyright (c) 2024 Rabeya Yousuf, Nurasyikin Yusof, Nur Afifah Suhemi, Nor Fadzliana Abdullah Thalith, Suria Abdul Aziz

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