Pharmacodynamic Potential of Sub-Gingivally Delivered Lovastatin in The Treatment of Patients with Chronic Localized Moderate Periodontitis: A Longitudinal Study

Authors

  • Hejal K Bhamtikar Department of Periodontology, NAMO Medical Education and Research Institute, Shri Vinoba Bhave Civil Hospital, Daman and Diu, Dadra and Nagar Haveli, India
  • Bindu R Nayar Department of Periodontology, Government Dental College Thiruvananthapuram, Kerala, Thiruvananthapuram, India
  • Lalbahadur L Sadhu Department of Oral Pathology and Microbiology, Ahmedabad Dental College and Hospital, Gujarat, Ahmedabad, India
  • Aayushi Gupta Department of Periodontology, Karnavati School of Dentistry, Karnavati University, Gujarat, Gandhi Nagar, India
  • Mainul Haque Department of Pharmacology and Therapeutics, Faculty of Medicine and Defence Health, National Defence University of Malaysia, Kuala Lumpur, Malaysia

DOI:

https://doi.org/10.3329/bjms.v24i2.81529

Keywords:

beneath the gums, subgingival, local drug delivery, mouth and tooth diseases, chronic periodontitis, effectiveness, therapeutic intervention, a fungal metabolite, lovastatin

Abstract

INTRODUCTION Periodontitis is an inflammatory disease caused by specific bacteria that leads to the progressive destruction of toothsupporting tissue. Treatment often includes non-surgical therapy, but antimicrobials may be needed to target bacteria. However, antimicrobial resistance can occur. Statins, particularly lovastatin, have shown promise in reducing inflammation and promoting bone formation in periodontitis treatment. Methods This study included 62 patients (12 males, 50 females) with chronic localized periodontitis aged 29-41. Patients were randomly divided into two groups: one treated with lovastatin gel (experiment group) and the other with a placebo (control group). After baseline measurements, subgingival scaling and gel application were performed. Data was analyzed using SPSS software (IBM SPSS Statistics for Windows, Version 22.0.Armonk, NY: IBM Corp.). Results This longitudinal study evaluated the efficacy of subgingival lovastatin in treating chronic localized moderate periodontitis. The study included 62 patients with no significant baseline differences. Significant improvements were observed in the lovastatin-treated experimental group for sulcus bleeding, pocket probing depth, clinical attachment, and bone fill (93.5% vs. 29% in the control group) Conclusion The study concludes that lovastatin’s local delivery adjunct to scaling and root planning reduces bleeding pocket depth and enhances clinical attachment and bone growth. Long-term, more extensive studies are needed to assess its full benefits.

Bangladesh Journal of Medical Science Vol. 24 No. 02 April’25 Page : 413-422        

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Published

2025-05-17

How to Cite

K Bhamtikar, H., R Nayar, B., L Sadhu , L., Gupta , A., & Haque , M. (2025). Pharmacodynamic Potential of Sub-Gingivally Delivered Lovastatin in The Treatment of Patients with Chronic Localized Moderate Periodontitis: A Longitudinal Study. Bangladesh Journal of Medical Science, 24(2), 413–422. https://doi.org/10.3329/bjms.v24i2.81529

Issue

Vol. 24 No. 2 (2025)

Section

Original Articles

License

Copyright (c) 2025 Hejal K Bhamtikar, Bindu R Nayar, Lalbahadur L. Sadhu , Aayushi Gupta , Mainul Haque

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