Cd40 doesn't Complement The Function Of Epstein-barr Virus (Ebv) Latent Membrane Protein 1 In B Cells Transformation

Authors

  • Mohammed Nazmul Ahsan Associate Professor, Dept. of Genetic Engineering and Biotechnology, University of Dhaka
  • Anwarul A Akhand Department of Genetic Engineering & Biotechnology University of Dhaka, Dhaka

DOI:

https://doi.org/10.3329/bjms.v11i2.8175

Keywords:

Epstein-Barr virus, CD40, CD40L, latent membrane protein, B cell transformation

Abstract

Objective: EpsteinBarr virus (EBV) latent membrane protein 1 (LMP1) is known to plays important role in B cells growth and transformation. LMP1 is considered to be a functional homologue of the CD40 receptor and they can activate many overlapping signaling pathways. In this study, we compared the function of CD40 with that of LMP1 in B cells transformation.

Materials and methods: Expression of CD40L was observed in infected B cells with LMP1 mutated EBV. To observe the expression reverse transcription-PCR were performed.

Results: This expression of CD40L did not support proliferation and transformation of B cell. Even in vitro proliferation and transformation of B cell infected with LMP1 deleted EBV supplemented with CD40L were also not observed.

Conclusion: Despite many similarities shared between CD40 and LMP1, CD40-CD40L interaction didnt complement on LMP1 mediated B cells transformation in vitro.

DOI: http://dx.doi.org/10.3329/bjms.v11i2.8175

Bangladesh Journal of Medical Science Vol. 11 No. 02 April 2012: 112-116

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Published

2012-07-26

How to Cite

Ahsan, M. N., & Akhand, A. A. (2012). Cd40 doesn’t Complement The Function Of Epstein-barr Virus (Ebv) Latent Membrane Protein 1 In B Cells Transformation. Bangladesh Journal of Medical Science, 11(2), 112–116. https://doi.org/10.3329/bjms.v11i2.8175

Issue

Vol. 11 No. 2 (2012)

Section

Original Articles

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