Synthesis and in vitro antibacterial activity of Cephradine Benzoate

Authors

  • M Ahmad Department of Pharmacy, Gono Bishwabidyalay, Mirzanagar, Savar, Dhaka
  • M Rahman Department of Pharmacy, Gono Bishwabidyalay, Mirzanagar, Savar, Dhaka
  • P Kumar Paul Department of Pharmacy, Gono Bishwabidyalay, Mirzanagar, Savar, Dhaka

DOI:

https://doi.org/10.3329/bjms.v10i3.8356

Keywords:

Cephradine benzoate, antibacterial activity, disc diffusion method

Abstract

Aims & Methods: The present study was undertaken to compare the antibacterial activity of a cephradine derivative with that of the parent antibiotic cephradine. Cephradine was converted to its benzoyl derivative by Schotten-Baumann method for the first time. Disc diffusion method was employed to find out the antibacterial activity against EPEC, ETEC, E. Agg, Salmonella typhi, Salmonella group B, Shigella boydii, Shigella dysenteriae 1, Shigella dysenteriae 2, Shigella flexinariae and Shigella sonnei. Melting point, TLC, HPLC, UV, FTIR and <sup>1</sup>H NMR studies were carried out to check the purity and confirm that the derivative was cephradine benzoate.

Results: The benzoyl derivative showed promising activity against tested bacteria. The results obtained from the study demonstrate that the benzoyl derivative could be a potential antibacterial agent.

Key words: Cephradine benzoate, antibacterial activity, disc diffusion method.  

DOI: http://dx.doi.org/ 10.3329/bjms.v10i3.8356

BJMS 2011; 10(3): 148-151

Downloads

Download data is not yet available.
Abstract
136
PDF
178

Downloads

How to Cite

Ahmad, M., Rahman, M., & Kumar Paul, P. (2011). Synthesis and in vitro antibacterial activity of Cephradine Benzoate. Bangladesh Journal of Medical Science, 10(3), 148–151. https://doi.org/10.3329/bjms.v10i3.8356

Issue

Vol. 10 No. 3 (2011)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.