The role of interleukins in the progression of liver fibrosis in patients with chronic hepatitis c

Authors

  • Iskakova Aigerim Nabievna West Kazakhstan Marat Ospanov Medical University
  • Astrakhanov Akezhan Rustemuly Infectious disease specialist of the Aktobe Regional Hepatology Center
  • Nurlanova Gulzhanat Nurlanovna West Kazakhstan Marat Ospanov Medical University
  • Kurmangazin Meyrambek Sagnaevich West Kazakhstan Marat Ospanov Medical University.
  • Kamzina Zauresh Kazakh-Russian Medical University.
  • Baubekova Asel Medical Astana University, Kazakhstan.
  • Donayeva Ainur West Kazakhstan Marat Ospanov Medical University.
  • Rysbekova Gulsim Kazakh-Russian Medical University
  • Bekova Nurgul West Kazakhstan Medical University named after Marat Ospanov, Aktobe, Republic of Kazakhstan
  • Zhenisbek Baubekov West Kazakhstan Marat Ospanov Medical University

DOI:

https://doi.org/10.3329/bjms.v25i2.88745

Keywords:

interleukins; liver fibrosis; chronic hepatitis C; inflammatory mediators; diagnostics; forecasting.

Abstract

Chronic hepatitis C (CHC) remains a major global health burden, affecting approximately 58 million people worldwide and causing nearly 400,000 deaths annually due to complications such as cirrhosis and hepatocellular carcinoma (HCC). According to the World Health Organization. Progressive liver fibrosis is a central mechanism leading to these adverse outcomes and significantly reduces patients’ quality of life. Interleukins play a crucial role in the inflammatory and fibrogenic processes associated with HCV infection. Proinflammatory cytokines, including IL-6, IL-1β, and TNF-α, contribute to hepatic stellate cell activation and collagen deposition, promoting fibrosis progression. Elevated levels of these cytokines have been shown to correlate with fibrosis severity. Recent studies also highlight the role of IL-33, IL-17, IL-25, and IL-1α as potential biomarkers of liver damage. Understanding cytokine-mediated mechanisms of fibrogenesis may improve early diagnosis, prognosis, and targeted therapeutic strategies in CHC patients.

BJMS, Vol. 25 No. 02 April’26 Page: 583-590

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Published

2026-04-19

How to Cite

Nabievna, I. A., Rustemuly, A. A., Nurlanovna, N. G., Sagnaevich, K. M., Zauresh, K., Asel, B., … Baubekov, Z. (2026). The role of interleukins in the progression of liver fibrosis in patients with chronic hepatitis c. Bangladesh Journal of Medical Science, 25(2), 583–590. https://doi.org/10.3329/bjms.v25i2.88745

Issue

Vol. 25 No. 2 (2026)

Section

Original Articles

License

Copyright (c) 2026 Iskakova Aigerim Nabievna, Astrakhanov Akezhan Rustemuly, Nurlanova Gulzhanat Nurlanovna, Kurmangazin Meyrambek Sagnaevich, Kamzina Zauresh, Baubekova Asel, Donayeva Ainur, Rysbekova Gulsim, Bekova Nurgul, Zhenisbek Baubekov

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