Serum Visfatin as a Predictive Biomarker of Metabolic Dysregulation in Obesity: Correlation with Lipid Parameters and Insulin Resistance

Authors

  • Sozdar Ayoub Adil College of Science, University of Zakho, Zakho, Kurdistan Region, Iraq
  • Lina Y Mohammed College of Science, University of Zakho, Zakho, Kurdistan Region, Iraq

DOI:

https://doi.org/10.3329/bjms.v25i2.88747

Keywords:

Obesity; Adipokines; Visfatin; Lipid profile; Insulin Resistance.

Abstract

Background and Objective Visfatin is a new adipocytokine primarily released by adipose tissue. It showed to affect both lipid and glucose metabolism and contribute to the chronic inflammatory condition associated with obesity. This study aimed to determine visfatin levels in obese and non-obese adult males and investigate their relationship with selected metabolic markers including insulin resistance and lipid profile. Materials and Methods Blood specimens were taken from 90 adult males categorized into two groups: obese and non-obese. Biochemical parameters were measured, including visfatin concentrations by using an enzyme-linked immunosorbent assay (ELISA) with a human visfatin ELISA kit, FBG, lipid profile, and hs-CRP using the Cobas 6000 c501 system, and FI using the Cobas 6000 c601 system. Results Serum visfatin levels were significantly elevated in obese subjects. FI, FBG, lipid profile, hs-CRP, HOMA-IR, and DBP are also significantly elevated in obese group. Visfatin showed a significant positive correlation with BMI, WC, FI, FBG, lipid profile, hs-CRP, HOMA-IR, and DBP, but a significant negative association with HDL-C. Conclusion The findings suggest that serum visfatin levels are markedly increased in obesity and are strongly linked with both insulin resistance and dyslipidemia. These results support the potential of visfatin as a predictive biomarker of metabolic dysregulation in obese individuals.

BJMS, Vol. 25 No. 02 April’26 Page: 602-608

Downloads

Download data is not yet available.
Abstract
30
PDF
20

Downloads

Published

2026-04-19

How to Cite

Adil, S. A., & Mohammed, L. Y. (2026). Serum Visfatin as a Predictive Biomarker of Metabolic Dysregulation in Obesity: Correlation with Lipid Parameters and Insulin Resistance. Bangladesh Journal of Medical Science, 25(2), 602–608. https://doi.org/10.3329/bjms.v25i2.88747

Issue

Vol. 25 No. 2 (2026)

Section

Original Articles

License

Copyright (c) 2026 Sozdar Ayoub Adil, Lina Y Mohammed

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.