Effect of Carbamazepine on Serum Cholesterol and Atherogenic Ratios in Young Adults with Epilepsy

Authors

  • Md Jafrul Kawsar Phase-B resident, Department of Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
  • Md Moniruzzaman Bhuiyan Professor, Department of Neurology, BSMMU, Dhaka, Bangladesh
  • Kanuj Kumar Barman Associate Professor, Department of Neurology, BSMMU, Dhaka, Bangladesh
  • Md Rafiqul Islam Professor and Chairman, Department of Neurology, BSMMU, Dhaka, Bangladesh
  • Hasan Zahidur Rahman Professor, Department of Neurology, BSMMU, Dhaka, Bangladesh
  • MA Hannan Professor, Department of Neurology, BSMMU, Dhaka, Bangladesh
  • Abu Nasir Rizvi Professor, Department of Neurology, BSMMU, Dhaka, Bangladesh
  • Chowdhury Neamul Hassan Refayet Phase-B resident, Neurology, Department of Neurology, BSMMU, Dhaka, Bangladesh
  • Habibur Rahaman Phase-B resident, Department of Neurology, BSMMU, Dhaka, Bangladesh
  • Rakib Hasan Mohammod Final Part Student, MD (Neurology), Dept. of Neurology,BSMMU,Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/bjn.v34i1.57533

Keywords:

Epilepsy, Carbamazepine, Total cholesterol (TC), Low density lipoprotein cholesterol (LDL-C), High density lipoprotein cholesterol (HDL-C), Atherogenic ratio

Abstract

Background: Epilepsy is a common chronic neurological disorder worldwide. Carbamazepine is one of the most commonly used antiepileptic drugs. It is a hepatic cytochrome P 450 enzyme inducer which is thought to cause alteration of serum lipids.

Objective: To evaluate the effect of carbamazepine on serum cholesterol and atherogenic ratios in young adult epileptic patients.

Materials and methods: This prospective study was conducted in the epilepsy clinic and Neurology OPD of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from December, 2017 to March, 2019. A total fifty seven newly diagnosed epileptic patients fulfilling the study criteria were studied. Serum TC, HDL-C, TG was measured by using Beckman Coulter- AU680 analyzer machine and LDL-C was calculated according to the Friedewald formula in the laboratory of Department of Biochemistry, BSMMU.

Results: The mean (±SD) serum TC, LDL, TG, TC/HDL-C and LDL-C/HDL-C were significantly increased (p-value < 0.001) at 3 months of carbamazepine therapy in comparison to the baseline levels. The mean (±SD) serum HDL was decreased at 3 months of therapy which was not statistically significant (p-value: 0.135).

Conclusion: Carbamazepine caused significant rise in serum TC, LDL-C, TG and atherogenic ratios (TC/HDL-C, LDL-C/HDL-C), and insignificant reduction in the serum HDL-C level after three months of therapy.

Bangladesh Journal of Neuroscience 2018; Vol. 34 (1): 32-38

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Published

2018-01-31

How to Cite

Kawsar, M. J. ., Bhuiyan, M. M. ., Barman, K. K. ., Islam, M. R. ., Rahman, H. Z. ., Hannan, M., Rizvi, A. N. ., Hassan Refayet, C. N. ., Rahaman, H. ., & Mohammod, R. H. . (2018). Effect of Carbamazepine on Serum Cholesterol and Atherogenic Ratios in Young Adults with Epilepsy. Bangladesh Journal of Neuroscience, 34(1), 32–38. https://doi.org/10.3329/bjn.v34i1.57533

Issue

Vol. 34 No. 1 (2018)

Section

Original Articles