Effect of Carbamazepine on Serum Cholesterol and Atherogenic Ratios in Young Adults with Epilepsy

Authors

  • Md Jafrul Kawsar Phase-B resident, Department of Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
  • Md Moniruzzaman Bhuiyan Professor, Department of Neurology, BSMMU, Dhaka, Bangladesh
  • Kanuj Kumar Barman Associate Professor, Department of Neurology, BSMMU, Dhaka, Bangladesh
  • Md Rafiqul Islam Professor and Chairman, Department of Neurology, BSMMU, Dhaka, Bangladesh
  • Hasan Zahidur Rahman Professor, Department of Neurology, BSMMU, Dhaka, Bangladesh
  • MA Hannan Professor, Department of Neurology, BSMMU, Dhaka, Bangladesh
  • Abu Nasir Rizvi Professor, Department of Neurology, BSMMU, Dhaka, Bangladesh
  • Chowdhury Neamul Hassan Refayet Phase-B resident, Neurology, Department of Neurology, BSMMU, Dhaka, Bangladesh
  • Habibur Rahaman Phase-B resident, Department of Neurology, BSMMU, Dhaka, Bangladesh
  • Rakib Hasan Mohammod Final Part Student, MD (Neurology), Dept. of Neurology,BSMMU,Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/bjn.v34i1.57533

Keywords:

Epilepsy, Carbamazepine, Total cholesterol (TC), Low density lipoprotein cholesterol (LDL-C), High density lipoprotein cholesterol (HDL-C), Atherogenic ratio

Abstract

Background: Epilepsy is a common chronic neurological disorder worldwide. Carbamazepine is one of the most commonly used antiepileptic drugs. It is a hepatic cytochrome P 450 enzyme inducer which is thought to cause alteration of serum lipids.

Objective: To evaluate the effect of carbamazepine on serum cholesterol and atherogenic ratios in young adult epileptic patients.

Materials and methods: This prospective study was conducted in the epilepsy clinic and Neurology OPD of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from December, 2017 to March, 2019. A total fifty seven newly diagnosed epileptic patients fulfilling the study criteria were studied. Serum TC, HDL-C, TG was measured by using Beckman Coulter- AU680 analyzer machine and LDL-C was calculated according to the Friedewald formula in the laboratory of Department of Biochemistry, BSMMU.

Results: The mean (±SD) serum TC, LDL, TG, TC/HDL-C and LDL-C/HDL-C were significantly increased (p-value < 0.001) at 3 months of carbamazepine therapy in comparison to the baseline levels. The mean (±SD) serum HDL was decreased at 3 months of therapy which was not statistically significant (p-value: 0.135).

Conclusion: Carbamazepine caused significant rise in serum TC, LDL-C, TG and atherogenic ratios (TC/HDL-C, LDL-C/HDL-C), and insignificant reduction in the serum HDL-C level after three months of therapy.

Bangladesh Journal of Neuroscience 2018; Vol. 34 (1): 32-38

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Published

2018-01-31

How to Cite

Kawsar, M. J. ., Bhuiyan, M. M. ., Barman, K. K. ., Islam, M. R. ., Rahman, H. Z. ., Hannan, M., … Mohammod, R. H. . (2018). Effect of Carbamazepine on Serum Cholesterol and Atherogenic Ratios in Young Adults with Epilepsy. Bangladesh Journal of Neuroscience, 34(1), 32–38. https://doi.org/10.3329/bjn.v34i1.57533

Issue

Vol. 34 No. 1 (2018)

Section

Original Articles