Association of Serum Ceruloplasmin Level with Parkinson’s’s Disease

Authors

  • Md Zahidul Islam Resident ( Phase B), Dept. of Neurology, BSMMU, Dhaka, Bangladesh
  • Kanuj Kumar Barman Associate Professor, Dept. of Neurology, BSMMU, Dhaka, Bangladesh
  • Md Ahsan Habib Associate Professor, Dept. of Neurology, BSMMU, Dhaka, Bangladesh
  • Md Rafiqul Islam Chairman, Dept. of Neurology, BSMMU, Dhaka, Bangladesh
  • Mehedi Hasan Resident ( Phase B), Dept. of Neurology, BSMMU, Dhaka, Bangladesh
  • Md Shofikul Islam Resident ( Phase B), Dept. of Neurology, BSMMU, Dhaka, Bangladesh
  • Muhammad Rezeul Huq Resident, (Phase B), Dept. of Neurology, BSMMU, Dhaka, Bangladesh
  • Imran Sarker Assistant Professor(CC), Dept. of Clinical Neurology, NINS&H, Dhaka, Bangladesh
  • Ajay Kumar Agarwalla Resident( Phase B), Dept. of Neurology, BSMMU, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/bjn.v34i2.57547

Keywords:

Parkinson’s disease, Ceruloplasmin, Substantia nigra

Abstract

Background: Parkinson’s disease, though a common neurodegenerative disease, is still elusive regarding its pathobiology. Neuronal degeneration in the midbrain substantia nigra by excess oxidative stress may play a role. As ceruloplasmin (Cp), a plasma protein is important to maintain intracellular iron homeostasis and reduce cellular oxidative stress, decreased serum Cp level may be an important factor in the pathogenesis of Parkinson’s disease.

Methods: This case-control study was conducted in the department of Neurology, BSMMU. Forty-five Parkinson’s disease patients and equal number of controls were selected. Serum ceruloplasmin level was measured in the department of Biochemistry and Molecular Biology, BSMMU.

Results: Mean serum Cp level was significantly lower (p-value <0.001) in case (27.64 mg/dl) than in control group (33.10 mg/dl).

Conclusion: The association of low serum Cp level with Parkinson’s disease may indicate a possible iron homeostasis abnormality as a pathogenic factor in Parkinson’s disease.

Bangladesh Journal of Neuroscience 2018; Vol. 34 (2): 63-65

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Published

2018-07-31

How to Cite

Islam, M. Z. ., Barman, K. K. ., Habib, M. A. ., Islam, M. R. ., Hasan, M. ., Islam, M. S. ., Huq, M. R. ., Sarker, I. ., & Agarwalla, A. K. . (2018). Association of Serum Ceruloplasmin Level with Parkinson’s’s Disease. Bangladesh Journal of Neuroscience, 34(2), 63–65. https://doi.org/10.3329/bjn.v34i2.57547

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Section

Original Articles