Current Status of Newborn Screening for the early Diagnosis of Congenital Hypothyroidism in Bangladesh

Authors

  • Mohammad Anwar Ul Azim National Institute of Nuclear Medicine and Allied Sciences (NINMAS), Bangladesh Atomic Energy Commission (BAEC), BSMMU, Shahbag, Dhaka-1000
  • Md Ariful Islam National Institute of Nuclear Medicine and Allied Sciences (NINMAS), Bangladesh Atomic Energy Commission (BAEC), BSMMU, Shahbag, Dhaka-1000
  • Sanchoy Chandra Biswasarma National Institute of Nuclear Medicine and Allied Sciences (NINMAS), Bangladesh Atomic Energy Commission (BAEC), BSMMU, Shahbag, Dhaka-1000
  • Md Jashim Uddin National Institute of Nuclear Medicine and Allied Sciences (NINMAS), Bangladesh Atomic Energy Commission (BAEC), BSMMU, Shahbag, Dhaka-1000
  • Zeenat Jabin National Institute of Nuclear Medicine and Allied Sciences (NINMAS), Bangladesh Atomic Energy Commission (BAEC), BSMMU, Shahbag, Dhaka-1000
  • Fatima Begum National Institute of Nuclear Medicine and Allied Sciences (NINMAS), Bangladesh Atomic Energy Commission (BAEC), BSMMU, Shahbag, Dhaka-1000
  • Shamim MF Begum National Institute of Nuclear Medicine and Allied Sciences (NINMAS), Bangladesh Atomic Energy Commission (BAEC), BSMMU, Shahbag, Dhaka-1000
  • Faridul Alam Ex-Director, NINMAS, BAEC, BSMMU, Shahbag, Dhaka-1000
  • Mizanul Hasan Ex-Director, NINMAS, BAEC, BSMMU, Shahbag, Dhaka-1000
  • Nurun Nahar Ex-Director, NINMAS, BAEC, BSMMU, Shahbag, Dhaka-1000
  • Jasmine Ara Haque
  • Hosne Ara Rahman Mitford, Bio-Science, BAEC, Dhaka
  • Gazi Abul Hossain Mymensingh, Bio-Science, BAEC, Dhaka
  • Shakila Zaman Rima Mymensingh, Bio-Science, BAEC, Dhaka
  • Kamrun Nahar Sylhet, Bio-Science, BAEC, Dhaka
  • Murshed Ali Rangpur, Bio-Science, BAEC, Dhaka
  • Jharna Das Khulna, Bio-Science, BAEC, Dhaka
  • Nafisa Jahan Barishal, Bio-Science, BAEC, Dhaka
  • Mostofa Shamim Ahsan Rajshahi, Bio-Science, BAEC, Dhaka
  • Shankar Kumar Dey Faridpur, Bio-Science, BAEC, Dhaka
  • Md Reajul Islam Cumilla, Bio-Science, BAEC, Dhaka
  • Md Abdul Awal Bogura, Bio-Science, BAEC, Dhaka
  • Md Sayeedul Alam Cox’s Bazar, Bio-Science, BAEC, Dhaka
  • BK Bose Dinajpur, Bio-Science, BAEC, Dhaka
  • AHM Roquibul Hoque Chattogram, Bio-Science, BAEC, Dhaka
  • Ashoke Kumar Paul Member, Bio-Science, BAEC, Dhaka
  • Faria Nasreen Director, Bio sciences Division, BAEC, Dhaka, Bangladesh
  • Sanowar Hossain
  • Fauzia Moslem Ex-Director, Bio-Science Division, BAEC, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/bjnm.v25i1.59636

Keywords:

Newborn Screening, Congenital hypothyroidism, TSH, IRMA, DELFIA.

Abstract

Background: Newborn screening programs signify early and presymptomatic detection of treatable disorders which authorize commencement of prompt medication to alleviate notable fatality. Newborn screening (NBS) for congenital hypothyroidism (CH) has been a successful public health initiative in preventive medicine over the last few decades. Previous pilot (1999-2006) and phase 1 (2006-2011) NBS program in Bangladesh reported an increased incidence compared to global data which urged to initiate a second phase NBS program for the detection of CH.

Materials & Methods: Neonates’ blood was collected from the umbilical cord or by heel prick and drawn on the Guthrie filter paper card. Thyroid-stimulating hormone (TSH) was measured from this filter paper by Immunoradiometric assay (IRMA) or Dissociation Enhanced Lanthanide Fluorescence Immunoassay (DELFIA) method.

Results: 123 out of 2,61,550 neonates have already been diagnosed with congenital hypothyroidism from September 2018 to August 2020, which represents an incidence of 1:2126.

Conclusion: Ongoing phase-2 project data is already showing some optimistic outcomes. Hence, a time-worthy sustainable policy should be implemented to mark this program as an effective one.

Bangladesh J. Nuclear Med. 25(1): 15-21, 2022

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Published

2022-05-25

How to Cite

Ul Azim, M. A., Islam, M. A. ., Biswasarma, S. C., Uddin, M. J. ., Jabin, Z. ., Begum, F., Begum, S. M., Alam, F. ., Hasan, M. ., Nahar, N., Haque, J. A. ., Rahman, H. A. ., Hossain, G. A. ., Rima, S. Z. ., Nahar, K. ., Ali, M., Das, J., Jahan, N. ., Ahsan, M. S. ., Dey, S. K. ., Islam, M. R. ., Awal, M. A., Alam, M. S., Bose, B., Hoque, A. R. ., Paul, A. K., Nasreen, F. ., Hossain, S., & Moslem, F. (2022). Current Status of Newborn Screening for the early Diagnosis of Congenital Hypothyroidism in Bangladesh. Bangladesh Journal of Nuclear Medicine, 25(1), 15–21. https://doi.org/10.3329/bjnm.v25i1.59636

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Original Articles