The Thyroglobulin paradox; An enigmatic case report of thyroid carcinoma with skeletal metastasis

Authors

  • Eshita Nandy MD, resident, National Institute of Nuclear Medicine & Allied Sciences (NINMAS), Dhaka
  • Kamrun Nahar Kainath MD, resident, National Institute of Nuclear Medicine & Allied Sciences (NINMAS), Dhaka
  • Jasmin Ferdous Associate Professor & PMO, NINMAS, Dhaka
  • Juwel Chowdhury Junior Consultant, 250 bedded General Hospital, Brahmanbaria , Chattogram
  • Pinky Rani Das MD, resident, National Institute of Nuclear Medicine & Allied Sciences (NINMAS), Dhaka
  • Fatema Morium MD, resident, National Institute of Nuclear Medicine & Allied Sciences (NINMAS), Dhaka
  • Khandaker Samia Shohana MD, resident, National Institute of Nuclear Medicine & Allied Sciences (NINMAS), Dhaka
  • Urnas Islam Senior Medical Officer, NINMAS, Dhaka
  • AKM Fazlul Bari Professor & Director, NINMAS, Dhaka

DOI:

https://doi.org/10.3329/bjnm.v28i2.89173

Keywords:

Bony metastasis, Papillary thyroid carcinoma (PTC), Thyroglobulin (Tg), Anti Thyroglobulin antibody (Anti Tg)

Abstract

Thyroglobulin (Tg) is frequently measured in follow-up of patients with differentiated thyroid carcinoma after total thyroidectomy and radioiodine therapy. A low stimulated Tg level (<1 ng/ml) associated with normal neck ultrasonography is considered as the most reliable criteria for complete remission in low-risk patients. We are reporting a case of middle-aged man with thyroid cancer and diffuse skeletal metastasis associated with low serum Tg level bringing a point of caution in evaluation of patients with low Thyroglobulin.

Bangladesh J. Nuclear Med. 28(2): 379-384, 2025

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Published

2026-05-19

How to Cite

Nandy, E., Kainath, K. N., Ferdous, J., Chowdhury, J., Das, P. R., Morium, F., … Bari, A. F. (2026). The Thyroglobulin paradox; An enigmatic case report of thyroid carcinoma with skeletal metastasis. Bangladesh Journal of Nuclear Medicine, 28(2), 379–384. https://doi.org/10.3329/bjnm.v28i2.89173

Issue

Vol. 28 No. 2 (2025)

Section

Case Reports

License

All rights reserved to Editor-in-Chief, Bangladesh Journal of Nuclear Medicine, Society of Nuclear Medicine, Bangladesh