Improving Specificity of Bone Scintigraphy: SPECT/CT Evaluation of Degenerative Spinal Uptake in 99mTc-MDP Bone Scintigraphy Mimicking Metastases

Authors

  • Mst Fahmoda Akter Assistant Professor & SMO, Institute of Nuclear Medicine and Allied Sciences (INMAS), Mitford, Dhaka
  • Samira Sharmin Associate Professor & PMO, Institute of Nuclear Medicine and Allied Sciences (INMAS), Mitford, Dhaka
  • Farida Yasmin Assistant Professor & SMO, Institute of Nuclear Medicine and Allied Sciences (INMAS), Mitford, Dhaka
  • Afroza Naznin SMO, Institute of Nuclear Medicine and Allied Sciences (INMAS), Suhrawardy, Dhaka
  • Mahmudur Rahman Mozumder Assistant Professor & SMO, Institute of Nuclear Medicine and Allied Sciences (INMAS), Mitford, Dhaka
  • Mariom Nusrat Medical Officer, Institute of Nuclear Medicine and Allied Sciences (INMAS), Mitford, Dhaka
  • Md Nazmul Hassan Sayed Dhaka Medical College Hospital, Dhaka
  • Hosne Ara Rahman Director & CMO, Institute of Nuclear Medicine and Allied Sciences (INMAS), Mitford, Dhaka

DOI:

https://doi.org/10.3329/bjnm.v28i2.89182

Keywords:

Bone scintigraphy, Metastasis, Degenerative disease, SPECT/CT, Oncology

Abstract

Bone scintigraphy is highly sensitive for detecting skeletal lesions. However, it is still difficult to differentiate metastases from degenerative bone disease, especially in older cancer patients. Here, two cases are presented with chronic back pain in the background of history of cancer in which whole-body bone scans showed focal “hot spots” suspicious for metastasis. Hybrid SPECT/CT imaging clarified that these findings consistent with degenerative disease. This distinction significantly altered clinical management, avoiding unnecessary investigations and further oncologic treatment. These cases highlight the critical role of SPECT/CT in enhancing diagnostic specificity and guiding appropriate patient care.

Bangladesh J. Nuclear Med. 28(2): 385-389, 2025

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Published

2026-05-19

How to Cite

Akter, M. F., Sharmin, S., Yasmin, F., Naznin, A., Mozumder, M. R., Nusrat, M., … Rahman, H. A. (2026). Improving Specificity of Bone Scintigraphy: SPECT/CT Evaluation of Degenerative Spinal Uptake in 99mTc-MDP Bone Scintigraphy Mimicking Metastases. Bangladesh Journal of Nuclear Medicine, 28(2), 385–389. https://doi.org/10.3329/bjnm.v28i2.89182

Issue

Vol. 28 No. 2 (2025)

Section

Case Reports

License

All rights reserved to Editor-in-Chief, Bangladesh Journal of Nuclear Medicine, Society of Nuclear Medicine, Bangladesh