Association of Toxoplasma Gondii Infection with Spontaneous Abortion

Authors

  • Mahmuda Sultana Junior Consultant, Department of Obstetrics and Gynaecology, Shaheed Tajuddin Ahmed Medical College & Hospital, Gazipur
  • Md Sazzad Hossain Assistant Professor, Department of Medicine, Shaheed Tajuddin Ahmed Medical College & Hospital, Gazipur
  • Farhana Dewan Professor & Head, Department of Obstetrics and Gynaecology, Shaheed Suhrawardy Medical College & Hospital, Dhaka
  • Jobaida Sultana Assistant Professor, Department of Obstetrics and Gynaecology, Shaheed Suhrawardy Medical College & Hospital, Dhaka
  • Maliha Rashid Professor of Obstetrics and Gynaecology, Former Head of, Department of Obstetrics and Gynaecology, Dhaka Medical College & Hospital, Dhaka

DOI:

https://doi.org/10.3329/bjog.v29i2.30486

Keywords:

Seroprevalence, Toxoplasma gondii, spontaneous abortion

Abstract

Objective: To evaluate whether there is any association of Toxoplasma gondii infection with spontaneous abortion.

Materials and Methods: This observational case control study was conducted in the Department of Obstetrics and Gynaecology, Dhaka Medical College Hospital, Dhaka (DMCH), over a period of one year from 31st December 2008 to 30th November 2009. A total 91 pregnant women were selected for this study. Among them 46 patients of spontaneous abortion were selected as case and 45 healthy pregnant women were selected as control purposively. Spontaneous abortion cases were diagnosed on the basis of history, clinical examination and USG findings. Patients with medical disorder, Rh-incompatibility, multiple pregnancy, cervical incompetence, septic abortion, threatened abortion, fibroid with pregnancy and uterine anomaly were excluded from the study. The clinical examination was done by standard method. Blood was collected from each subject, serum was separated. Main outcome measure was presence of toxoplasma antibodies in spontaneous abortion cases. Antibody was detected by ELISA method. A p value of <0.5 was considered as significant.

Results: In both groups there was no difference in age, gestational age, socioeconomic status, living standard and educational status. Toxoplasma specific IgM was detected in higher percentage of women with spontaneous abortion (15.2%) than with controls (0%), which is statistically significant (<0.05). Seroprevalence for past Toxoplasma infection (IgG) was similar in both the groups, 17.4% and 8.9% for case and control respectively (p>0.05). Though there is no association between seropositivity and level of education, place of living, contact with cat, occupational status, parity and past history of spontaneous abortion, seropositivity is higher in the poor socioeconomic group.

Conclusion: Seroprevalence for recent Toxoplasma gondii infection is higher in women with spontaneous abortion.

Bangladesh J Obstet Gynaecol, 2014; Vol. 29(2) : 87-93

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Author Biography

Mahmuda Sultana, Junior Consultant, Department of Obstetrics and Gynaecology, Shaheed Tajuddin Ahmed Medical College & Hospital, Gazipur



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Published

2016-11-27

How to Cite

Sultana, M., Hossain, M. S., Dewan, F., Sultana, J., & Rashid, M. (2016). Association of Toxoplasma Gondii Infection with Spontaneous Abortion. Bangladesh Journal of Obstetrics &Amp; Gynaecology, 29(2), 87–93. https://doi.org/10.3329/bjog.v29i2.30486

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Original Articles