Anticonvulsant activity of bioflavonoid gossypin

Authors

  • Duraisami Rasilingam Department of Pharmacognosy, Nandha College of Pharmacy, Koorapalayam Pirivu, Perundurai Main Road, Erode 638052, Tamil Nadu
  • Srinivasan Duraisamy Department of Pharmacology, Raja Muthiah Dental Collge, Annamalai Universituy, Annamalai Nagar, Chidambaram 608 002. Tamil Nadu
  • Ramaswamy Subramanian Department of Pharmacology, Arupadai Veedu Medical College, Pondicherry 607402

DOI:

https://doi.org/10.3329/bjp.v4i1.1081

Keywords:

Anticonvulsant, Bio-flavonoid, Gossypin, Pentelenetetrazole, Strychnine

Abstract

The anticonvulsant activity of gossypin was investigated by studying the effects on seizures induced by pentelentetrazole, strychnine and maximal electroshock convulsive methods in mice. Gossypin (10 and 20 mg/kg) significantly reduced the duration of convulsion in tonic seizure induced by pentelenetetrazole (95 mg/kg, intraperitoneally). Gossypin (20 mg/kg p.o) significantly reduced the tonic extensor convulsion induced by strychnine and maximum electroshock-induced convulsions. The data obtained suggest that gossypin have anticonvulsant property and may probably be affecting both GABA aminergic and glycine inhibitory mechanism.

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Author Biography

Duraisami Rasilingam, Department of Pharmacognosy, Nandha College of Pharmacy, Koorapalayam Pirivu, Perundurai Main Road, Erode 638052, Tamil Nadu

Professor

References

Achliya GS, Wadodkar SG, Darle AK. Evaluation of CNS activity of Bramhi Ghrita. Indian J Pharmacol. 2005; 37: 33-36.

Babu BH, Jayaram HN, Nair MG, Ajay Kumar KB, Padikkala J. Free radical scavenging, antitumor and anti-carcinogenic activity of gossypin. J Exp Clin Cancer Res. 2003; 6: 2281-89.

De Sarro A, Cecchetti V, Fravolini V, Naccari F, Tabarrini O, De Sarro G. Effects of novel b-desfluroquinolones and classic quinolones on pentelenetetrazole-induced seizures in mice. Antimicrob Agents Chemother. 1999; 43: 1729-36.

Gale MK. GABA and epilepsy basic concepts from preclinical research. Epilepsia 1992; 33 Suppl: S3-12.

Gupta YK, Malhotra J. Adenosinergic system as an endogenous anticonvulsant mechanism. J Physiol Pharmacol. 1997; 41; 329-43.

Loscher W, Schmidt D. Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res. 1988; 2; 145-81.

Mattson RH. Drug treatment of partial epilepsy. Adv Neurol. 1992; 57: 643-50.

Meldrum BS. GABA agonists as antiepileptic agents. Adv Biochem Psycopharmacol. 1981; 26: 207-17.

McNamara JO. Drugs effective in the therapy of the epilepsies. In: Goodman and Gillmans The pharmacological basis of therapeutics. Hardman, JG, Limbird LE (eds). 10th ed. New York, McGraw-Hill, 2001, pp 521-39.

Porter RJ, Meldrum BS. Antiseizure drugs. In: Basic and clinical pharmacology. Katzung BG (ed). New York, Lange Medical Books/McGraw-Hill, 2001, pp 403-17.

Salahdeen HM, Yemitan OK. Neuropharmacological effects of aqueous leaf extract of Bryophyllum pinnatum in mice. African J Bio Med Res. 2006; 9: 101-07.

Sayin U, Cengiz S, Altug T. Vigabatin as an anticonvulsant against penteletetrazole seizures. Pharmacol Res. 1993; 28: 325-31.

Vidyasagar J, Srinivas M, Nagulu M, Venkatasam A, Udyakiran B, Krishna DR. Protein binding study of gossypin by equilibrium dialysis. Curr Trends Biotech Phar. 2008; 2: 396-401.

Viola H, Wasowski C, Levidestein M, Wolfmane, Silveria R, Dajas F, Medina JH, Paladini AC. Apigenin, a componant of Marlicaria recutita flowers, is a central benzodiazepine receptors-legand with anxiolytic effects. Planta Med. 1995; 61: 213-16.

Westmoreland BF, Benarroch EE, Dube JR, Regan TJ, Sandok BA. Medical neurosciences. Mayo Foundation Rochester 1994, pp 307-12.

White HS. Clinical significance of animal seizure models and mechanism of action, studies of potential antiepileptic drugs. Epilepsia 1995; 38 Suppl: S9-17.

WHO. Epilepsy: Etiology, epidemiology and prognosis. www.who.int/entire/mediacentre/factsheets/fs165/en/-25k-16jan2006.

Wolfman C, Viola H, Paladini A, Dajas F, Media JH. Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passifloara coerulea. Pharmacol Biochem Behav. 1994; 47: 1-4.

Yemitan OK, Adeymi OO. CNS depressant activity of Lecaniodisurs cupanioides. Fitoterpia 2005; 76: 412-18.

Yemitan OK, Salahdeen HM. Neurosedative and muscle relaxant activities of aqueous extract of Bryophyllum pinnatum. Fitoterpia 2005; 76: 187-93.

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Published

2008-09-17

How to Cite

Rasilingam, D., S. Duraisamy, and R. Subramanian. “Anticonvulsant Activity of Bioflavonoid Gossypin”. Bangladesh Journal of Pharmacology, vol. 4, no. 1, Sept. 2008, pp. 51-54, doi:10.3329/bjp.v4i1.1081.

Issue

Vol. 4 No. 1 (2009)

Section

Research Articles

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