Anticonvulsant activity of bioflavonoid gossypin
DOI:
https://doi.org/10.3329/bjp.v4i1.1081Keywords:
Anticonvulsant, Bio-flavonoid, Gossypin, Pentelenetetrazole, StrychnineAbstract
The anticonvulsant activity of gossypin was investigated by studying the effects on seizures induced by pentelentetrazole, strychnine and maximal electroshock convulsive methods in mice. Gossypin (10 and 20 mg/kg) significantly reduced the duration of convulsion in tonic seizure induced by pentelenetetrazole (95 mg/kg, intraperitoneally). Gossypin (20 mg/kg p.o) significantly reduced the tonic extensor convulsion induced by strychnine and maximum electroshock-induced convulsions. The data obtained suggest that gossypin have anticonvulsant property and may probably be affecting both GABA aminergic and glycine inhibitory mechanism.
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