Antimicrobial activity of Leucas clarkei

Authors

  • Surya Narayan Das Gayatri College of Pharmacy, Jamadarpali, Sambalpur, Odisha
  • Varanasi Jagannath Patro Roland Institute of Pharmaceutical Sciences, Berhampur, Odisha
  • Subas Chandra Dinda School of Pharmaceutical Education & Research, Berhampur University, Berhampur 760 007, Odisha

DOI:

https://doi.org/10.3329/bjp.v7i2.10894

Keywords:

Antibacterial, Antifungal, Leucas clarkei

Abstract

The antimicrobial potency of the whole plant of Leucas clarkei have been studied using the soxhlet extracts of petroleum ether, benzene, chloroform and ethanol extract against Gram-positive bacteria (two strains), Gram-negative bacteria (two strains) and two fungi strains by disc diffusion method. Micro-dilution methods, for the determination of minimal inhibition concentration (MIC) and the minimal bactericidal and fungicidal concentration (MBC, MFC). The ethanol extract at a concentration of 30 to 60 µg/disc and chloroform extract at a concentration 60 µg/disc   showed significant activity against all the bacteria and fungus. All the extracts of L. clarkei have got moderate action but chloroform and ethanol extracts have got significant activity against Candida krusei, Candida albicans, Escherichia coli, Salmonella typhi, Staphylococcus aureus, and Bacillus subtilis. This may be due to phytochemicals such as phytosterols, alkaloid, tannins, phenolic compounds and flavonoids present in the extracts.

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Author Biography

Surya Narayan Das, Gayatri College of Pharmacy, Jamadarpali, Sambalpur, Odisha

Associate Professor

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Published

2012-07-04

How to Cite

Das, S. N., V. J. Patro, and S. C. Dinda. “Antimicrobial Activity of Leucas Clarkei”. Bangladesh Journal of Pharmacology, vol. 7, no. 2, July 2012, pp. 135-9, doi:10.3329/bjp.v7i2.10894.

Issue

Vol. 7 No. 2 (2012)

Section

Research Articles

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