Effect of safflower yellow on platelet activating factor mediated platelet activation in patients with coronary heart disease

Authors

  • Damin Huang Department of Cardiology, Xinhua (Chongming) Hospital of Shanghai Jiaotong University, Shanghai 202150
  • Yingmin Lu Department of Cardiology, Xinhua (Chongming) Hospital of Shanghai Jiaotong University, Shanghai 202150
  • Xiaohan Luo Department of Cardiology, Xinhua (Chongming) Hospital of Shanghai Jiaotong University, Shanghai 202150
  • Laixin Shi Department of Cardiology, Xinhua (Chongming) Hospital of Shanghai Jiaotong University, Shanghai 202150
  • Jinchun Zhang Department of Cardiology, Xinhua (Chongming) Hospital of Shanghai Jiaotong University, Shanghai 202150
  • Junxian Shen Department of Cardiology, Xinhua (Chongming) Hospital of Shanghai Jiaotong University, Shanghai 202150
  • Minmin Bao Department of Cardiology, Xinhua (Chongming) Hospital of Shanghai Jiaotong University, Shanghai 202150
  • Lei Song Department of Cardiology, Xinhua (Chongming) Hospital of Shanghai Jiaotong University, Shanghai 202150
  • Caiwen Wei Department of Cardiology, Xinhua (Chongming) Hospital of Shanghai Jiaotong University, Shanghai 202150
  • Hongsong Li Department of Cardiology, Xinhua (Chongming) Hospital of Shanghai Jiaotong University, Shanghai 202150
  • Zhihua Li Department of Cardiology, Xinhua (Chongming) Hospital of Shanghai Jiaotong University, Shanghai 202150

DOI:

https://doi.org/10.3329/bjp.v7i2.11094

Keywords:

5-HT, Platelet activating factor, Platelet aggregation, Safflower yellow

Abstract

The platelet aggregation and 5-HT release by washed platelet from coronary heart disease patients following platelet activating factor (PAF) treatment were detected by turbidimetry and O-phthalaldehyde assay. The free calcium concentration in the platelets was measured with the fura-2/AM probe fluorescent technique. Results showed safflower yellow could inhibit the PAF induced washed platelet aggregation and 5-HT release, which were in a safflor-yellow-dose dependent manner. When the PAF was 2.0×10-9 mol/L, the inhibition rate of platelet aggregation was 26.2%, 41.3%, 58.1%, 81.2%, and the inhibition rate of 5-HT release was 3.7%, 11.9%, 29.9% and 54.4% after treatment with safflower yellow at 0.21, 0.42, 0.85 and 1.69 g/L, respectively. The study concludes safflower yellow can inhibit the PAF induced platelet aggregation, 5-HT release by platelets and elevation of free calcium in platelets.

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Published

2012-07-09

How to Cite

Huang, D., Y. Lu, X. Luo, L. Shi, J. Zhang, J. Shen, M. Bao, L. Song, C. Wei, H. Li, and Z. Li. “Effect of Safflower Yellow on Platelet Activating Factor Mediated Platelet Activation in Patients With Coronary Heart Disease”. Bangladesh Journal of Pharmacology, vol. 7, no. 2, July 2012, pp. 140-4, doi:10.3329/bjp.v7i2.11094.

Issue

Vol. 7 No. 2 (2012)

Section

Research Articles

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