Effects of Gymnema lactiferum leaves on glycemic and lipidemic status in type 2 diabetes subjects

Authors

  • Thushari Bandara Department of Biochemistry, Faculty of Medical Sciences, University of Sri Jayewardenepura
  • Begum Rokeya Biomedical Research Group, BIRDEM, K. N. Islam Avenue, Dhaka
  • Sakina Khan Biomedical Research Group, BIRDEM, K. N. Islam Avenue, Dhaka
  • Liaquat Ali Biomedical Research Group, BIRDEM, K. N. Islam Avenue, Dhaka
  • Sagarika Ekanayake Department of Biochemistry, Faculty of Medical Sciences, University of Sri Jayewardenepura
  • Errol R. Jansz Department of Biochemistry, Faculty of Medical Sciences, University of Sri Jayewardenepura
  • Kandiah Balasubramanium Biotech (Pvt) Ltd, Jaffna

DOI:

https://doi.org/10.3329/bjp.v4i2.1195

Keywords:

Blood glucose, Cholesterol, Gymnema lactiferum, HbA1C, LDL, Type 2 diabetics

Abstract

Gymnema lactiferum var. lactiferum is a climber distributed in many South Asian countries. It is reported that the diabetic patients in Sri Lanka use G. lactiferum leaves as a treatment for diabetes. However, scientific data is not available on this plant. A clinical trial was conducted including 26, type 2 diabetic patients with hypercholesterolemia. The treatment group received a suspension of G.  lactiferum leaf powder twice daily for  four weeks. Blood parameters of both groups (treated and control) were determined at the beginning and the end of the study period. Study indicates significant effects on fasting blood sugar (p=0.002), cholesterol (p=0.004), and LDL lowering (p=0.023) and a significant postprandial glucose lowering effect (p=0.026 for 60 min and p=0.022 for 120 min, after four weeks). In spite of the short study period, a significant reduction (p=0.012) in HbA1C levels was also observed.

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References

Allain CC, Poon LS, Chan CSG, Richmond W, Fu PC. Clin Chem. 1974; 20: 470-75.

Asha SK, Anila L, Vijayalakshmi NR. Flavonoids from Garcinia cambogia lower lipid levels in hyper cholesterolemic rats. Food Chem. 2001; 72: 289-94.

Ayurveda Phamacopia Vol. I. part 3. Published by the Department of Ayurveda, Colombo, Sri Lanka; 1961, p 114.

Dassanayake MD, Fosberg FR. A revised hand book to the flora of Ceylon. Vol. IV. New Delhi, Amering Publishers, 1983, pp 97-98.

Friedewald WT, Levy RI, Fedrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972; 18: 499-502.

Hainline AJR, Cooper GR, Olansky AS. CDC Survey of high-density lipoprotein cholesterol measurement: A report. Atlanta Lipid Standardization Program. Center for Disease Control; 1980, p 3.

Imai K, Nakachi K. Cross sectional study of effects of drinking green tea on cardiovascular and liver disease. Bri Med J. 1995; 310: 693-96.

International Federation of Clinical Chemistry, Scientific Committee. J Clin Chem Clin Biochem. 1980; 18: 521-34.

Kono S, Shinchi K, Ikeda N, Yanai F, Imanichi K. Green tea consumption and serum lipid profiles: a cross sectional study in Northern Kyushu, Japan. Prev Med. 1992; 21: 526-31.

Kunst A, Draeger B, Ziegenhorn J. Methods of enzymatic analysis. Vol. 6. Weinheim, W Germany, Deerfield Beach, 1984, pp 178-85.

Matsuda H, Chisaka T, Kubumura Y, Yamahara J, Savada T, Fujima H, Kimura H. Effect of crude drugs on experimental hypercholesterolemia-1-tea and its active principles. J Ethnopharmacol. 1986; 17: 213-24.

Mayer TK, Freedman ZR. Protein glycosylation in diabetes mallitus: A review of laboratory measurements and of their clinical utility. Clin Chem Acta 1983; 127: 147-84.

Stancu C, Sina A. Statin: Mechanism of action and effects. Bucharesh, Romania, Nicolas Simoinesae Institute of Cellular Biology and Pathology, 2001.

Sudheesh S, Presanna Kumar G, Vijayakumar S, Vijayalakshmi NR. Hypolipidemic effect of flavonoids from solanum melongena. Plant Foods Human Nutr. 1997; 51: 321-30.

Tietz NW. Clinical guide to Laboratory tests. 2nd ed. Philadelphia, USA, W.B. Saunders Company, 1990, pp 554-56.

Toro G, Ackermann PG. Practical clinical chemistry. Boston, Little Brown and Co., 1975, p 154.

Valsa AK, Ushakumary B, Vijayalakshmi MR. Effect of catechin on lipid metabolism. J Clin Biochem Nutr. 1995; 19: 175-82.

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Published

2009-04-23

How to Cite

Bandara, T., B. Rokeya, S. Khan, L. Ali, S. Ekanayake, E. R. Jansz, and K. Balasubramanium. “Effects of Gymnema Lactiferum Leaves on Glycemic and Lipidemic Status in Type 2 Diabetes Subjects”. Bangladesh Journal of Pharmacology, vol. 4, no. 2, Apr. 2009, pp. 92-95, doi:10.3329/bjp.v4i2.1195.

Issue

Vol. 4 No. 2 (2009)

Section

Research Articles

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