Evaluation of anti-diarrheal activity of Diospyros malabarica bark extract

Authors

  • Mahesh S. Rode SVPM?S College of Pharmacy, Malegoan, Baramati, Pune
  • Mohan G. Kalaskar R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule
  • Namdev Y. Gond SVPM'S College of Pharmacy, Malegoan, Baramati, Pune
  • Sanjay J. Surana R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule

DOI:

https://doi.org/10.3329/bjp.v8i1.13157

Keywords:

Castor oil, Diarrhea, Diospyros malabarica

Abstract

The present study was undertaken to evaluate the anti-diarrheal activity of the ethanolic extracts of Diospyros malabarica Kostel bark at concentration (200, 400 mg/kg) using different experimental model such as castor oil-induced diarrhea, gastrointestinal motility and enteropooling. The D. malabarica extract showed significant anti-diarrheal activity in a dose dependent manner. The results collectively demonstrate the D. malabarica could act by attributed to an anti-electrolyte permeability action, inhibit the PGE2 centrally and also anti-muscarinic activity to give anti-diarrheal effects. Result of charcoal meal test also suggested its anti-muscarinic activity. These findings indicate that ethanolic extract of the D. malabarica displays good anti-diarrheal activity, corroborating the folk use of D. malabarica preparations and contributing for its pharmacological validation.

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Additional Files

Published

2013-01-14

How to Cite

Rode, M. S., M. G. Kalaskar, N. Y. Gond, and S. J. Surana. “Evaluation of Anti-Diarrheal Activity of Diospyros Malabarica Bark Extract”. Bangladesh Journal of Pharmacology, vol. 8, no. 1, Jan. 2013, pp. 49-53, doi:10.3329/bjp.v8i1.13157.

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Section

Research Articles