Xanthine oxidase inhibitory activity of compounds from Chythrantus claneianus

Authors

  • Anar Sahib Gojayev Department of Biochemistry and Biotechnology, Faculty of Biology, Baku State University, AZ 1148
  • Jean Jules Kezetas Bankeu Department of Chemistry, Faculty of Science, University of Bamenda, P. O. Box 39 Bambili
  • Angelbert Fusi Awantu Department of Chemistry, Faculty of Science, University of Bamenda, P. O. Box 39 Bambili
  • Eric René Sieliatchom Nkanwen Chemistry Department, Faculty of Science, University of Dschang, P.O. Box 67, Dschang
  • Muhammad Shaiq Ali I.C.C.B.S., International Center for Chemical and Biological Sciences, University of Karachi 75270
  • Bruno Ndjakou Lenta Higher Teachers Training College, University of Yaoundé I, P.O. Box 47, Yaoundé
  • Akif Alakbar Guliyev Department of Biochemistry and Biotechnology, Faculty of Biology, Baku State University, AZ 1148
  • Didérot Tchamo Noungoué TWAS Research Unit, Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P. O. Box 812 Yaoundé
  • Silvère Augustin Ngouela TWAS Research Unit, Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P. O. Box 812 Yaoundé
  • Etienne Tsamo TWAS Research Unit, Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P. O. Box 812 Yaoundé

DOI:

https://doi.org/10.3329/bjp.v8i1.13485

Keywords:

Chythrantus claneianus, rheumatism, xanthine oxidase inhibitor

Abstract

Phytochemical investigation of the stem bark and the trunk of Chythrantus claneianus led to the isolation of six known compounds named β-sitosterol (1), umbelliferone (2), scopoletin (3), benjaminamide (4), β-sitosterol-3-O-β-D-glucopyranoside (5) and panconoside B (6). All these compounds were isolated for the first time from this plant species. The chemical structures of isolates were elucidated on the basis of 1 and 2 D-NMR spectra and other spectroscopic techniques including UV–vis, FT-IR, HR-ESIMS and HR-FABMS. The isolates were tested in vitro for their inhibitory properties towards xanthine oxidase enzyme. Compounds 2, 3 and 6 showed weak inhibitory activities on the enzyme with IC50 values ranging from 307 µM for compound 6 to 475 µM for compound 3, while the extract and compounds 1, 4 and 5 showed extremely weak activities with inhibition percentage less than 50%.

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Published

2013-02-04

How to Cite

Gojayev, Anar Sahib, et al. “Xanthine Oxidase Inhibitory Activity of Compounds from Chythrantus Claneianus”. Bangladesh Journal of Pharmacology, vol. 8, no. 1, Feb. 2013, pp. 78-83, doi:10.3329/bjp.v8i1.13485.

Issue

Vol. 8 No. 1 (2013)

Section

Research Articles

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