Potential anti-diabetic activity of Bombax ceiba

Authors

  • Chetan Bhavsar R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule
  • Gokul S. Talele NGSPM?s College of Pharmacy, Brahma Valley Educational campus, Trimbak road, Anjaneri, Nashik

DOI:

https://doi.org/10.3329/bjp.v8i2.13701

Keywords:

Kantesavar, Toranmal, Hypoglycemic, Hypolipidemic, Streptozotocin

Abstract

Bombax ceiba bark extract was evaluated for its hypoglycemic and hypolipide-mic potential through normal and streptozotocin-induced diabetic rats administered with graded oral doses (200, 400, 600 mg/kg/day) for 21 days. The results showed that a dose of 600 mg/kg of B. ceiba extract is the most effective to cause significant (p<0.001) hypoglycemic and/or hypolipidemic effects on  streptozotocin-induced diabetic rats. This dose also significantly (p<0.001) lowered the total cholesterol and triglyceride level in severely diabetic rats. Phytochemical and GC-MS studies confirmed the presence of the triterpenoid compounds in the extract, which may account for its significant hypoglycemic activity. The present study thus provides a scientific rationale for the traditional use of this plant in the management diabetes.

Downloads

Download data is not yet available.
Abstract
3332
Download
1433 Read
325

References

Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974; 20: 47075.

Ansari MM, Ahmad J, Ahmad A, Ansari SH. Pharmacognostical, phytochemical and biological evaluations of the stem bark of Bombax ceiba Linn. (Semul). Hamdard Med. 2007; 50: 119-33.

Gandhare B, Soni N Hemant JZ. In vitro antioxidant activity of Bombax ceiba. Int J Biomed Res. 2012; 1: 31-36.

Bierman EL, Amaral JAP, Belknap BH. Hyperlipidemia and diabetes mellitus. Diabetes 1966; 15: 675-79.

Burstein M, Scholnick HR, Morfin R. Rapid method for isolation of lipoprotein from human serum by precipitation with polyanions. J Lipid Res. 1970; 11: 58395.

Elsner M, Guldbakke B, Tiedge M, Munday R, Lenzen S. Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin. Diabetologia 2000; 43: 1528-33.

Esmaeili MA, Yazdanparas R. Hypoglycemic effect of Teucrium polium: Studies with rat pancreatic islets. J Ethnopharmacol. 2004; 95: 27-30.

Faizi S, Zikr-Ur-Rehman S, Versiani MA. Shamiminol: A new aromatic glycoside from the stem bark of Bombax ceiba. Nat Prod Commun. 2011; 6: 1897-900.

Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem. 1972; 18: 499-502.

Hai-Xue Kuang, Hong-Wei Li, Qiu-Hong Wang, Bing-You Yang, Zhi-Bin Wang, Yong-Gang Xia. Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba Molecules. 2011; 16: 4642-51.

Jacques RA, Santos JG, Darivab C, Vladimir Oliveira J, Caramao EB. GC/MS characterization of mate tea leaves extracts obtained from high-pressure CO2 extraction. J Supercritic Fluids. 2007; 40: 354-59.

Kedar P, Chakrabarti CH. Effects of bittergourd Momordica charantia seed and glibenclamide in streptozotocin induced diabetes mellitus. Indian J Exp Biol. 1982; 20: 232-35.

Kirtikar KR, Basu BD. Indian medicinal plants. Vol II, 2nd edn. Dehradun, International Book Distribution, 1987.

Muller PH, Schmulling RM, Liebih HM, Eggstein M. A fully enzymatic triglyceride determination. J Clin Chem Clin Biochem. 1977; 15: 45764.

Patel SS, Verma NK, Rathore B, Nayak G, Singhai AK, Singh P. Cardioprotective effect of Bombax ceiba flowers against acute adriamycin-induced myocardial infarction in rats. Rev Bras Farmacogn 2011; 21: 704-09.

Sugihara Y, Nojima H, Matsuda H, Murakami T, Yoshikawa M, Kimura I. Antihyperglycemic effects of gymnemic acid IV, a compound derived from Gymnema sylvestre leaves in streptozotocin-diabetic mice. J Asian Nat Prod Res. 2000; 2: 321-27.

Tan MJ, Ye JM, Turner N, Hohnen-Behrens C, Ke CQ, Tang CP, et al. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem Biol. 2008; 15: 263-73.

The wealth of India, dictionary of Indian raw material and Industrial products. Vol-II:B. Publication and Information Directorate, CSIR, New Delhi, 2005.

Trinder P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem. 1969; 6: 2427.

Verma V, Jalalpure SS, Sahu A, Lokesh KB, Yache P. Bombax ceiba Linn: Pharmacognostical, phytochemistry, ethnobotany, and pharmacology studies. Internatinale Pharmacutica Sci. 2011; l: 62-68.

Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes, estimates for the year 2000 and projections for 2030. Diabetes Care. 2004; 27: 1047-53.

Downloads

Additional Files

Published

2013-02-26

How to Cite

Bhavsar, C., and G. S. Talele. “Potential Anti-Diabetic Activity of Bombax Ceiba”. Bangladesh Journal of Pharmacology, vol. 8, no. 2, Feb. 2013, pp. 102-6, doi:10.3329/bjp.v8i2.13701.

Issue

Vol. 8 No. 2 (2013)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).