Oxidative metabolic changes in pleural fluid of tuberculosis patients

Authors

  • Y. Narsimha Reddy Department of Pharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009
  • S. Vasudeva Murthy Department of Pharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009
  • D. R. Krishna Department of Pharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009
  • M. C. Prabhakar Department of Pharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009

DOI:

https://doi.org/10.3329/bjp.v4i1.1443

Keywords:

Antioxidant, Catalase, Free radicals, Lactate dehydrogenase, Lipid peroxidation

Abstract

The pleural fluid was aspirated from the tuberculous patients both untreated and under treatment with three months anti-tuberculosis therapy. The amount of malondialdehyde, lactate dehydrogenase, and total protein contentin pleural fluid of untreated tuberculous patients were found to be significantly higher when compared with under treatment group. The pleural fluid total antioxidantlevels were significantly lower in untreated cases in comparison to under treatment. Decrease in the total antioxidant status was more pronounced in untreated cases, established that antioxidants were nearly completely utilized to scavenge the free radicals. Our findings further support the importance of antioxidants in the treatment of tuberculous patient.

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Additional Files

Published

2008-11-11

How to Cite

Reddy, Y. N., S. V. Murthy, D. R. Krishna, and M. C. Prabhakar. “Oxidative Metabolic Changes in Pleural Fluid of Tuberculosis Patients”. Bangladesh Journal of Pharmacology, vol. 4, no. 1, Nov. 2008, pp. 69-72, doi:10.3329/bjp.v4i1.1443.

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Section

Research Articles