Hepatoprotective and nephroprotective activity of hydroalcoholic extract of Ipomoea staphylina leaves
DOI:
https://doi.org/10.3329/bjp.v8i3.14845Keywords:
Carbon tetrachloride, Gentamicin, Ipomoea staphylina, Nephroprotective, NephrotoxicityAbstract
The present study was undertaken to investigate the protective effect of hydroalcoholic extract of leaves of Ipomoea staphylina against carbon tertrachloride- and gentamicin-induce hepatotoxicity and nephrotoxicity in rats respectively. The extract (200 mg/kg, p.o) showed hepatoprotective activity against carbon tetrachloride-induced hepatotoxicity by significantly (p<0.001) reducing the levels of AST, ALT, ALP, total bilirubin and significantly (p<0.001) increasing the serum total protein. The extract also showed nephro-protective activity against gentamicin-induced nephrotoxicity by significantly (p<0.001) reducing the levels of blood urea, blood urea nitrogen (BUN), serum creatinine and significantly (p<0.001) increasing the serum total protein. The extract also improves the histology of the liver and kidney. The total phenolic content and the total flavonoid content of the extract were 94.59 ± 2.54 mg gallic acid equivalent/g and 44.68 ± 2.00 mg rutin equivalent/g respectively.
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AL-Howiriny TA, AL-Sohaibani MO, AL-Said MS, Rafatullah S. Hepatoprotective properties of Commiphora opobalsamum ("Balessan"), a traditional medicinal plant of Saudi Arabia. Drugs Exp Clin. 2004; 30: 213-20.
Firdous M, Nitesh SC. Evaluation of antiulcer activity of Ipomoea staphylina. Pharmacologyonline 2009; 3: 195-99.
Firdous SM, Raju K. In vivo and in vitro antiinflammatory activity of leaves of Ipomoea staphylina. Int J Pharm Pharm Sci. 2012; 4: 339-43.
Firdous SM, Raju K, Pallab H. Evaluation of hepatoprotective activity of saponin of Momordica dioica roxb. Against CCl4 induced hepatic injury in rats. Pharmacologyonline. 2008; 3: 487-94.
Harlalka GV, Patil CR, Patil MR. Protective effect of Kalanchoe pinnata pers. (crassulaceae) on gentamicin-induced nephrotoxicity in rats. Indian J Pharmacol. 2007; 39: 201-05.
Kaplowitz N, Aw TY, Simon FR, Stolz A. Drug induced hepatotoxicity. Ann Intern Med. 1986; 104: 826.
Kim DO, Jeong SW, Lee CY: Antioxidant capacity of phenolic phytochemicals from various cultivars of plums. Food Chem. 2003; 81: 321-26.
Krishna BKL, Mruthunjaya K, Patel JA. Antioxidant and hepatoprotective activity of leaf extract of Justica gendrerussa. Int J Biol Chem. 2009; 3: 99-110.
Levey AS, Atkins R, Coresh J, Cohen EP, Collins AJ, Eckardt KU, Nahas ME, Jaber BL, Jadoul M, Levin A, Powe N R, Rossert J, Wheeler DC, Lameire N, Eknoyan G. Chronic kidney disease as a global public health problem: Approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes. Kidney Int. 2007; 10: 1-5.
Manokaran S, Jaswanth A, Sengottuvelu S, Nandhakumar J. Hepatoprotective activity of Aerva lanata Linn. against Paracetamol induced hepatotoxicity in rats. Res J Pharm Tech. 2008; 1: 398-400.
OECD, 2002. Acute oral toxicity. Acute oral toxic class method guideline 423 adopted 23.03.1996. In: Eleventh Addendum to the, OECD, guidelines for the testing of chemicals organisation for economics co-operation, development, Paris, June, 2000, p 11.
Park YS, Jung ST, Kang SG, Heo BK, Arancibia-Avila P, Toledo F, Drzewiecki J, Namiesnik J, Gorinstein S. Antioxidants and proteins in ethylene-treated kiwifruits. Food Chem. 2008; 107: 640-48.
Poormoosavi SM, Behmanesh MA, Najafzadeh H. Effect of cimetidine on gentamicin-losartan induced-nephrotoxicity in rats. Afr J Pharm Pharmacol. 2010; 4: 341-45.
Punitha ISR, Shirwaikar A, Shirwaikar A. Antidiabetic activity of benzyltetraisoquinoline alkaloid berberine in streptozotocin nicotinamide induced type 2 diabetic rats. Diabetologia Croatica. 2005; 34: 117-28.
Saleem TSM, Chetty SM, Ramkanth S, Rajan VST, Kumar KM, Gauthaman K. Hepatoprotective herbs: A review. Int J Res Pharm Sci. 2010; 1: 1-5.
Sanjay J, Vinod KD, Neelzesh M, Vijay A. Antioxidant and hepatopraotective activity of hydroalcoholic and aqueous extracts of Amorphophallus campanulatus roxb. tubers. Acta Poloniac Pharm Drug Res. 2009; 66: 423-28.
Rajib A, Monirul I, Israt JB. Hepatoprotective activity of methanol extract of some medicinal plants against carbon tetrachloride-induced hepatotoxicity in rats. Eur J Sci Res. 2009; 37: 302-10.
Reddy DP, Kota R, Renuka S, Anarthe SJ, Nulgumnall, Manjunathaiah R. Isolation, characterization of phytoconstituents and pharmacological screening of Ipomoea staphylina. Asian J Pharm Clin Res. 2013; 6: 30-33.
Wahid AM, Vijay RS, Satish BB. Hepatoprotective activity of hydroalcoholic extract leaves of Alocassie indica. Indian J Exp Biol. 2009; 47: 816-21.
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