Antihyperlipidemic and renoprotective activities of methanolic extract of Canscora decussata extract in alloxan-induced diabetic rabbits
DOI:
https://doi.org/10.3329/bjp.v8i3.15506Keywords:
Alloxan, Atherogenic index, Canscora decussata, Coronary risk index, Antihyperlipidemic, RenoprotectiveAbstract
The current study was designed to evaluate the hypolipidemic and renopro-tective effects of methanolic extract of powdered Canscora decussata whole plant in the diabetic rabbits. Thirty rabbits were divided into five groups having 6 animals each including normal and diabetic controls groups, the remaining groups received methanolic extract in 400 and 600 mg/kg doses and another group got pioglitazone (3 mg/kg) for 30 days. Serum levels of triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, albumin, globulin and total proteins were estimated by using commercially available kits. The results showed that extract significantly (p<0.01) decreased the raised parameters including triglyceride, total cholesterol and LDL-cholesterol, atherogenic index, Coronary risk index up to normal values compared to diabetic rabbits. However, it significantly increased HDL-cholesterol, albumin, globulin and total protein levels. Therefore, it is suggested that methanolic extract of C. decussata exerts hypolipidemic and renoprotective effects in the alloxan-induced diabetic rabbits.
Downloads
449
199 Read
3
References
Akhtar MS, Iqbal J. Evaluation of hypoglycemic effect of Achyranthes aspera, Linn. In normal and diabetic rabbits. J Ethnopharmacol. 1991; 31: 49-57.
Akhtar MS, Khan MA, Malik MT. Hypoglycemic activity of Alpinia galangal rhizome and its extracts in rabbits. Fitoterapia 2002; 73: 623-28.
Akhtar MS, Nadeem M, Rashid, Bashir S. Hypoglycaemic activity of different fractions of Berberis aristata root-bark in normal and alloxan diabetic rabbits. Can. J. App. Sci., 2011; 2: 16-28.
Alamgeer, Rashid M, Bashir S, Mushtaq MN, Khan HU, Malik MNH, Qayyum A, Shafeeq ur Rahaman M. Comparative hypoglycemic activity of different extracts of Teucrium stocksianum in diabetic rabbits. Bangladesh J Pharmacol. 2013; 8: 186-93.
Alberti KGMM, Zimmet P, Defronzo RA, Keen H. International textbook of diabetes mellitus. 2nd ed. Chichester, John Wiley and Sons, 1997, p 1379.
Alberti KGMM, Problems related to definitions and epidemiology of type 2 diabetes mellitus: Studies throughout the world. Diabetologia, 1993; 36; 978-84.
Bag AK, Mumtaz SMF. Hepatoprotective and nephroprotective activity of hydroalcoholic extract of Ipomoea staphylina leaves. Bangladesh J Pharmacol. 2013; 8: 263-68.
Bandara T, Rokeya B, Khan S, Ali L, Ekanayake S, Jansz ER, Balasubramanium K. Effects of Gymnema lactiferum leaves on glycemic and lipidemic status in type 2 diabetes subjects. Bangladesh J Pharmacol. 2009; 4: 92-95.
Batteridge J. Lipid disorders in diabetes mellitus. In: Textbook of diabetes. William G (eds). 2nd ed. London, Blackwell Science, 1997, pp 1-31.
Bayle C, Atzpodien EA, Freshour G. Peroxisome proliferators activated receptor-γ agonist provides superior renal protection versus angiotensin-converting enzyme inhibition in a rat model of type 2 diabetes with obesity. J Pharmacol Exp Ther. 2003; 307: 854-60.
Begum NA, Dewan ZF, Nahar N, Mamun MIR. Effect of n-hexane extract of Nigella sativaon gentamicin-induced nephrotoxicity in rats. Bangladesh J Pharmacol. 2006; 1: 16-20.
Bhavsar C, Talele GS. Potential anti-diabetic activity of Bombax ceiba. Bangladesh J Pharmacol. 2013; 8: 102-06.
Bhowmik A, Khan LA, Akhter M, Rokeya B. Studies on the antidiabetic effects of Mangifera indica stem-barks and leaves on non diabetic, type 1 and type 2 diabetic model rats. Bangladesh J Pharmacol. 2009; 4: 110-14.
Bnouham M, Mekhfi H, Legssyer A, Ziyyat A .Medicinal plants used in the treatment of diabetes in Morocco. Int J Diabetes Metab. 2002; 10: 33-50.
Buckingham RE, Al-Barazanji KA, Toseland CN. Peroxisome proliferators-activated receptor-γ agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats. Diabetes 1998; 47: 1326-34.
Centers for Disease Control and Prevention (CDC). Incidence of end-stage renal disease among persons with diabetes-United States, 1990-2002.
MMWR Morb Mortal Wkly Rep. 2005; 54: 1097-1100.
Devaki K, Beulah U, Akila G, Narmadha R, Gopalakrishnan VK. Glucose lowering effect of aqueous extract of Bauhinia tomentosa L. on alloxan induced type 2 diabetes mellitus in Wistar albino rats. JBCP. 2011; 2: 167-74.
El-Hilaly J, Hmamouchi M, Lyoussi B. Ethnobotanical studies and economic evaluation of medicinal plants in Taounate province (Northern Morocco). J Ethnopharmacol. 2003; 86: 149-58.
Friedewald WT, Levy RI, Fradrickson DS. Estimation of concentration of low density lipoprotein cholesterol in plasma without the use of preparative ultracentrifuge. Clin Chem. 1972; 18: 499-502.
Grover JK, Yadav SP. Pharmacological actions and potential uses of Momordica charantia: A review. J Ethnopharmacol, 2004; 93: 123-32.
Hamlaoui S, Samti O, Mokni M, Limam N, Carrier A, Limam F, Amri M, Aouani E, Marzouki L. Protective effect of grape seed and skin extract on high dosage garlic-induced renal oxidative stress. Bangladesh J Pharmacol. 2012; 7: 54-62.
Irshad N, Akhtar MS, Bashir S, Malik A, Kamal, Y .Hypoglycaemic effects of Canscora decussata (Schult) whole-plant in normal and alloxan-induced diabetic rabbits. J Ethnopharmacol. 2012; (under consideration)
Kakadiya J,Shah NJ. Hypoglycemic and hypolipidemic activity of pioglitazone in normal and streptozotocin-nicotinamide induced diabetic rats. Pharmacologyonline 2010; 1: 1-7.
Khanam M, Dewan ZF. Effects of the crude and the n-hexane extract of Nigella sativa Linn. (kalajira) upon diabetic rats. Bangladesh J Pharmacol. 2009; 4: 17-20.
Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy 19th ed. Pune, Nirali Prakashan, 2002; pp 524-25.
Kulandaivel S, Bajpai P, Sivakumar T. Anti-hyperglycemic activity of Trichosanthes tricuspidata root extract. Bangladesh J Pharmacol. 2013; 8: 305-10.
Laakso M. Epidemiology of diabetic dyslipidemia. Diabetic Rev; 1995; 3; 408-22.
Maciejewski R, Rucinski P, Burski K, Figura T. Changes in glucose, cholesterol and serum lipid fraction levels in experimental diabetes. Ann Univ Mariae Curie Sklodowska. 2001; 56: 363-68.
McCarthy KJ, Routh RE, Shaw W. Troglitazone halts diabetic glomerulosclerosis by blockade of mesangial expansion. Kidney Int. 2000; 58: 2341-50.
Mumtaz SMF, Paul S, Bag AK. Effect of Sechium edule on chemical induced kidney damage in experimental animals. Bangladesh J Pharmacol. 2013; 8: 28-35.
Natarajan S, Glick H, Criqui M, Horowitz D, Lipsitz SR, Kinosian B. Cholesterol measures to identify and treat individuals at risk for coronary heart disease. Am. J Prev Med. 2003; 25: 50-57.
Ohga S, Shikata K, Yozai, K. Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-?B activation. Am J Physiol Renal Physiol. 2007; 292: 1141-50.
Olajide OA, Awe S, Makinde JM. Purgative effect of the methanol extract of Morinda, Lucida. Fitoterapia 1999; 70: 199-204.
Pattanayak S, Nayak SS, Panda D, Shende V. Hypoglycemic of Cajanus scarabaeoides in glucose overloaded and streptozotocin-induced diabetic rats. Bangladesh J Pharmacol. 2009; 4: 131-35.
Prajapati DD, Patel NM, Savadi RV, Akki KS, Mruthunjaya K. Alleviation of alloxan-induced diabetes and its complications in rats by Actinodaphne hookeri leaf extract. Bangladesh J Pharmacol. 2008; 3: 102-06.
Ravi S, Sadashiva CT, Tamizmani T, Balasubramanian T, Rupeshkumar M, Balachandran I. In vitro glucose uptake by isolated rat hemi-diaphragm study of Aegle marmelos Correa root. Bangladesh J Pharmacol. 2009; 4: 65-68.
Rahman AU, Zaman K. Medicinal plants with hypoglycemic activity. J Ethnopharmacol. 1989; 26: 1-55.
Rang HP, Dale, MM, Ritter JM, Moore PK (eds). Atherosclerosis and lipoprotein metabolism. In: The text-book of pharmacology. London, Churchill Livingstone/Elsevier, 2003, p 311.
Roman-Ramos R, Florez-Saenz JL, Alarcon-Aguilar FJ. Antihyperglycemic effect of some edible plants. J Ethnopharmacol. 1995; 48: 25-32.
Saha BK, Bhuiyan MNH, Mazumder Haque KKMF. Hypoglycemic activity of Lagerstroemia speciosa L. extract on streptozotocin-induced diabetic rat: Underlying mechanism of action. Bangladesh J Pharmacol. 2009; 4: 79-83.
Sen S, De B, Devanna N, Chakraborty R. Hypoglycaemic and hypolipidemic effect of Meyna spinosa leaves in high fat diet-alloxan induced type 2 diabetic rats. Bangladesh J Pharmacol. 2013; 8: 181-85.
Shah Y, Tangalos EG, Petersen RC. Mild cognitive impairment. When is it a precursor to Alzheimer's disease. Geriatrics 2000; 55: 65-68.
Shani J, Gold Schmied A, Joseph B, Abronson Z, Sneman FG. Hypoglycemic effects of Trigonella faenum graecum and Lupinus termis (Leguminosae) seed and their major alkaloids in alloxan-diabetic and normal rats. Arch Int Pharmacodyn Ther. 1974; 210, 27-37.
Sivajothi V, Dey A, Jayakar B, Rajkapoor B. Antihyperglycemic and antioxidant effect of Phyllanthus rheedii on streptozotocin-induced diabetic rats. Iranian J Pharma Res. 2008; 7: 53-59.
Sperling MA, Saunders PA. Diabetes mellitus. In: Nelson textbook of pediatrics. Behrman RE, Kliegman RM, Jenson HB (eds). 2000, pp 1767-91.
Sumana G, Suryawanshi SA. Effect of Vinca rossa extracts in treatment of alloxan diabetes in male albino rats. Ind J Exp Bio. 2001; 39: 748-59.
Tahraoui A, El-Hilaly J, Israili ZH, Lyoussi B. Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia province). J Ethnopharmacol. 2007; 110: 105-17.
Tatiya AU, Puranik PM, Surana SJ, Patil YS, Mutha RE. Evaluation of hypolipidemic, antidiabetic and antioxidant activity of Eulophia herbacea tubers. Bangladesh J Pharmacol. 2013; 8: 269-75.
Tedong L, Dimo T, Dzeufi PD, Asongalem E, Sokeng DS, Callard P, Flejou F, Kamtchouing P, .Antihyperglycemic and renal protective activities of Anacardium occidentale leaves in streptozotocin induced diabetic rats. Afr J Trad CAM. 2006; 3: 23-35.
Ullah N, Khan MA, Khan T, Ahmad W. Bioactive traditional plant Cinnamomum zeylanicum successfully combat against nephrotoxic effects of aminoglycosides. Bangladesh J Pharmacol. 2013; 8: 15-21.
Way KJ, Kata IN, King GL. Protein kinase C and the development of diabetic vascular complication. Diabet Med. 2001; 18: 945.
Wojtowicz Z, Wrona W, Kis G, Blaszczak M, Solecka A. Serum total cholesterol, triglyceride and high density lipoprotein levels in rabbits during the course of experimental diabetes. Ann Univ Mariae Curie Sklodowska, 2004; 59; 258-60.
Ziyat A, Legssyer A, Mekhfi H, Dassouli A, Serhrouchni M, Benjelloun W. Phytotherapy of hypertension and diabetes in oriental Morocco. J Ethnopharmacol. 1997; 58: 45-54.
Additional Files
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
