Gastrodin attenuates vincristine-induced mechanical hyperalgesia through serotonin 5-HT1A receptors

Authors

  • Zheng-Gang Guo Department of Anesthesiology, The First Affiliation Hospital, Chinese PLA Hospital, Beijing 100 048
  • Xiao-Pen Jia Department of Anesthesiology, The First Affiliation Hospital, Chinese PLA Hospital, Beijing 100 048
  • Xiao-Jun Su Department of Anesthesiology, The First Affiliation Hospital, Chinese PLA Hospital, Beijing 100 048
  • Ping Li Department of Anesthesiology, The First Affiliation Hospital, Chinese PLA Hospital, Beijing 100 048
  • Jian-Hua Hao Department of Anesthesiology, the First Affiliation Hospital, Chinese PLA Hospital, Beijing, China 100048

DOI:

https://doi.org/10.3329/bjp.v8i4.16836

Keywords:

Gastrodin, Mice, Neuropathic pain, Vincristine, Von Frey filament

Abstract

Gastrodia elata Blume (Orchidaceae) is an old traditional Chinese medicine with demonstrated analgesic efficacy in humans. However, the potential analgesic effect of its active component, gastrodin, has not been systematically studied. This work described the anti-hyperalgesic effect of gastrodin in a mouse model of chemotherapeutic agent vincristine-induced neuropathic pain. Gastrodin (0.05-0.8 mg/kg) dose-dependently reverted the mechanical hyperalgesia in mice. In addition, the anti-hyperalgesic effect of gastrodin was significantly blocked by a selective serotonin 5-HT1A receptor antagonist WAY100635 (1 mg/kg). In contrast, gastrodin did not significantly alter the general locomotor activity in mice. Taken together, this study demonstrated that gastrodin possesses robust analgesic efficacy in mice and may be a novel analgesic for the management of neuropathic pain.

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Author Biography

Jian-Hua Hao, Department of Anesthesiology, the First Affiliation Hospital, Chinese PLA Hospital, Beijing, China 100048

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Published

2013-12-25

How to Cite

Guo, Z.-G., X.-P. Jia, X.-J. Su, P. Li, and J.-H. Hao. “Gastrodin Attenuates Vincristine-Induced Mechanical Hyperalgesia through Serotonin 5-HT1A Receptors”. Bangladesh Journal of Pharmacology, vol. 8, no. 4, Dec. 2013, pp. 414-9, doi:10.3329/bjp.v8i4.16836.

Issue

Vol. 8 No. 4 (2013)

Section

Research Articles

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