Investigations on the anti-diabetic potential of novel marine seaweed Sargassum longiotom against alloxan-induced diabetes mellitus: A pilot study

Authors

  • Stalin Selvaraj Centre for Nanotechnology & Advanced Biomaterials, School of Chemical & Biotechnology, SASTRA University, Thanjavur
  • Sampathkumar Palanisamy Department of Chemistry & Biosciences, Srinivasa Ramanujan Centre, SASTRA University, Kumbakonam

DOI:

https://doi.org/10.3329/bjp.v9i2.17304

Keywords:

Diabetes, Hypoglycemic, Hypolipidemic, Sargassum longiotom

Abstract

The present study evaluated the hypoglycemic effect of brown algae Sargassum longiotom in alloxan-induced diabetic rats. After the treatment with S. longiotom extract, there is a significant reduction (p<0.001) in blood glucose when compared with the diabetic control group. Moreover the ethanolic extract of S. longiotom significantly reduces (p<0.001) the levels of   triglycerides, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol dose dependent manner. Alternatively, it increases the high-density lipoprotein cholesterol level in the treated groups. The values of SGOT, SGPT and ALP have been significantly reduced (p<0.001) in the treated rats when compared to diabetic control. Thus, the present study indicates that the ethanolic extract of seaweed S. longiotom posses very effective hypoglycemic and hypolipidemic effect on the alloxan-induced diabetic rats compared to the reference drug glibenclamide.

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References

Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998; 15: 539-53.

Aravindan S, Delma CR, Thirugnanasambandan SS, Herman TS, Aravindan N. Anti-pancreatic cancer deliverables from sea: First-hand evidence on the efficacy, molecular targets and mode of action for multifarious polyphenols from five different brown-algae. PLoS One 2013; 8: e61977.

Bilic N. The mechanism of alloxan toxicity: An indication for alloxan complexes in tissues and alloxan inhibition of 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulphonic acid (SITS) binding for the liver cell membrane. Diabetologia 1975; 11: 39-43.

Bowman RE, Wolf RC. A rapid and specific ultramicro method for total serum cholesterol. Clin Chem. 1962; 8: 302-09.

de Sousa E, Zanatta L, Seifriz I, Creczynski-Pasa TB, Pizzolatti MG, Szpoganicz B, Silva FR. Hypoglycemic effect and anti-oxidant potential of kaempferol-3,7-O-(alpha)-dirhamnoside from Bauhinia forficata leaves. J Nat Prod. 2004; 67: 829-32.

Dembinska-Kiec A, Mykkanen O, Kiec-Wilk B, Mykkanen H. Anti-oxidant phytochemicals against type 2 diabetes. Br J Nutr. 2008; 99 (E Suppl 1): ES109-17.

Dixit Y, Kar A. Protective role of three vegetable peels in alloxan induced diabetes mellitus in male mice. Plant Foods Hum Nutr. 2010; 65: 284-89.

El-Alfy AT, Ahmed AA, Fatani AJ. Protective effect of red grape seeds proanthocyanidins against induction of diabetes by alloxan in rats. Pharmacol Res. 2005; 52: 264-70.

Guerra Dore CM, Faustino Alves MG, Santos ND, Cruz AK, Camara RB, Castro AJ, Guimaraes Alves L, Nader HB, Leite EL. Antiangiogenic activity and direct antitumor effect from a sulfated polysaccharide isolated from seaweed. Microvasc Res. 2013; 88: 12-18.

Hamden K, Allouche N, Damak M, Elfeki A. Hypoglycemic and anti-oxidant effects of phenolic extracts and purified hydroxytyrosol from olive mill waste in vitro and in rats. Chem Biol Interact. 2009; 180: 421-32.

Ikewuchi JC, Onyeike EN, Uwakwe AA, Ikewuchi CC. Effect of aqueous extract of the leaves of Acalypha wilkesiana 'Godseffiana'Muell Arg (Euphorbiaceae) on the hematology, plasma biochemistry and ocular indices of oxidative stress in alloxan induced diabetic rats. J Ethnopharmacol. 2011; 137: 1415-24.

Kumar S, Sharma S, Vasudeva N. Screening of antidiabetic and antihyperlipidemic potential of oil from Piper longum and piperine with their possible mechanism. Expert Opin Pharmacother. 2013; 14: 1723-36.

Middleton JE. Experience with a glucose-oxidase method for estimating glucose in blood and CSF. Br Med J. 1959; 1(5125): 824-26.

Nagaraju R, Joshi AKR, Rajini PS. Estimation of plasma triglycerides with correction for free glycerol by orlistat inhibition of lipoprotein lipase activity. Analy Biochem. 2013; 439: 44-46.

Salib JY, Michael HN, Eskande EF. Anti-diabetic properties of flavonoid compounds isolated from Hyphaene thebaica epicarp on alloxan induced diabetic rats. Pharmacog Res. 2013; 5: 22-29.

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Published

2014-04-23

How to Cite

Selvaraj, S., and S. Palanisamy. “Investigations on the Anti-Diabetic Potential of Novel Marine Seaweed Sargassum Longiotom Against Alloxan-Induced Diabetes Mellitus: A Pilot Study”. Bangladesh Journal of Pharmacology, vol. 9, no. 2, Apr. 2014, pp. 194-7, doi:10.3329/bjp.v9i2.17304.

Issue

Vol. 9 No. 2 (2014)

Section

Research Articles

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