Anti-acne activity of Casuarina equisetifolia bark extract: A randomized clinical trial

Authors

  • Yousra Shafiq Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi
  • Baqir Shyum Naqvi Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, Karachi
  • Ghazala H. Rizwani Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi
  • Muhammed Usman Nigehban Pharmacy, Dhoraji, Karachi
  • Barkat Ali Shah Model Skin Laser Clinic, Karachi
  • Muhammad Aslam Department of Pharmacology, Faculty of Pharmacy, University of Karachi
  • Bushra Hina Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi

DOI:

https://doi.org/10.3329/bjp.v9i3.19342

Keywords:

Anti-acne, Acne vulgaris, Casuarina equisetifolia, Benzoyl peroxide

Abstract

The objective of this study was to evaluate the clinical efficacy of Casuarina equisetifolia bark extract (5% cream) in comparison with benzoyl peroxide as the standard drug for acne vulgaris. After exclusion, fifty patients were included in the study (n=50) with age group distribution between 17-34 years of age. Patients were distributed into Group 1 (5% cream) and Group 2 (benzoyl peroxide), and were advised to apply the herbal cream twice a day topically. The clinical efficacy of the herbal cream and severity of acne vulgaris was assessed by Cook's acne grading scale. Results revealed that there was no significant difference found in both test and standard control groups. Further, remarkable improvement was found in acne grading in the test group.

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References

Adityan B, Thappa DM. Profile of acne vulgaris: A hospital-based study from South India. Indian J Dermatol Venereol Leprol. 2009; 75: 272- 78.

Ali Y, Naqvi BS, Rizwani GH, Hina B, Shadmani A. Antileishmanial and Insecticidal activities of some medicinal plants of Pakistan. J Parasitol. 2013; 103: 132-38.

Allen LV, Nicholas G, Ansel HC. Ansels Pharmaceutical dosage forms and drug delivery systems. 8th ed. Philadelphia, Lippincott Williams & Wilkins, 2005, p 272-90.

Azad HL, Shahida H, Tanzeel A, Mohd A. Effect of a polyherbal Unani formulation in acne vulgaris: A preliminary study. J Ayurveda & Integ Med. 2012; 3: 180-83.

Burkhart CG, Burkhart CN, Lehmann PF: Acne: A review of immunologic and microbiologic factors. J Post Med. 1999; 75: 328-31.

Burns T, Breathnach S, Cox N, Griffiths C. Rook's Textbook of dermatology. 7th ed. Oxford, Blackwell Publishing Ltd, 2004, pp 2137-50.

Chomnawong MT, Surassmo S, Nakoolkarn VS, Gritsanapan W. Antimicrobial effects of Thai medicinal plants against acne inducing bacteria. J Ethnopharmacol. 2005; 101: 330-33.

Cook CH, Centner RL, Michael SE. An acne grading method using photographic standards. Arch Dermatol. 1979; 115: 571-75.

Eady EA, Farmery MR, Ross JI, Cove JH, Cunliffe WJ. Effects of benzoyl peroxide and erythromycin alone and in combination against antibiotic-sensitive and -resistant skin bacteria from acne patients. Br J Dermatol. 1994; 131: 331-36.

Gumgumjee NM, Hajar AS. Antimicrobial efficacy of Casuarina equisetifolia extracts against some pathogenic microorganisms. J Med Plants Res. 2012; 47: 5819-25.

Hunter JAA, Savin JA, Dahl MV. Clinical dermatology. 2nd ed. United Kingdom, Blackwell Publishing Ltd, 2003, pp 148-55.

Kaur P, Kaur S, Kumar S, Singh P. Rubia cordifolia L. and Glycyrrhiza glabra L. medicinal plants as potential source of COX-2 inhibitors. Am J Biomed Sci. 2010; 2: 108-20.

Lalla JK, Nandedkar SY, Paranjape MH, Talreja NB. Clinical trials of Ayurvedic formulations in the treatment of acne vulgaris. J Ethnopharmacol. 2001; 78: 99-102.

Magin PJ, Adam J, Pond CD, Smith W. Topical and oral CAM in acne: A review of the empirical evidence and a consideration of its context. Compl Ther Med. 2006; 14: 6276.

Shweta K, Swarnalatha S. Topical herbal therapies an alternative and complementary choice to combat acne. Res J Med Plant. 2011; 5: 650-69.

Spittle MF, Ranu HS, Hutton WC, Challoner AV, Burlin TE. A comparison of different treatment regimes on the visual appearance and mechanical properties of mouse skin. Br J Radiol. 1980; 53: 697702.

Thiboutot D, Gilliland K, Light J, Lookingbill D. Androgen metabolism in sebaceous glands from subjects with and without acne. Arch Dermatol. 1999; 135: 1041-45.

Thube SA, Patil MJ. Antiacne effect of polyherbal gel formulation in Sprague-Dawley rats. Int J Res Ayurveda Pharm. 2013; 4: 398-401.

Tony B, Stephen B, Neil C, Christopher G. Rooks Textbook of dermatology. 7th ed. United Kingdom, Blackwell Publishing Ltd, 2004, pp 2137-50.

Vijayalakshmi A, Tripura A, Ravichandiran V. Development and evaluation of anti-acne products from Terminalia arjuna bark. Int J Chem Tech Res. 2011; 3: 320-27.

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Published

2014-08-01

How to Cite

Shafiq, Y., B. S. Naqvi, G. H. Rizwani, M. Usman, B. A. Shah, M. Aslam, and B. Hina. “Anti-Acne Activity of Casuarina Equisetifolia Bark Extract: A Randomized Clinical Trial”. Bangladesh Journal of Pharmacology, vol. 9, no. 3, Aug. 2014, pp. 337-41, doi:10.3329/bjp.v9i3.19342.

Issue

Vol. 9 No. 3 (2014)

Section

Clinical Trial

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