Hypoglycemic activity of aqueous leaf extract of Limonia elephantum in alloxan-induced diabetic rats
DOI:
https://doi.org/10.3329/bjp.v9i3.19705Keywords:
Alloxan, Antidiabetic, Glucose tolerance test, Hypoglycemic, Limonia elephantumaAbstract
The hypoglycemic activity of the aqueous leaf extract of Limonia elephantum was evaluated. The extract was administered orally 1,000 mg/kg to normal and alloxan-induced (55 mg/kg body weight, i.v) diabetic rats. The hypoglycemic effect of the extract was statistically significant with an oral dose of 1,000 mg/kg and was comparable to that of the effect produced by standard antidiabetic agent, metformin 1.5 mg/kg. The extract increased the glucose tolerance using oral glucose tolerance test.
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