Hypoglycemic activity of aqueous leaf extract of Limonia elephantum in alloxan-induced diabetic rats
DOI:
https://doi.org/10.3329/bjp.v9i3.19705Keywords:
Alloxan, Antidiabetic, Glucose tolerance test, Hypoglycemic, Limonia elephantumaAbstract
The hypoglycemic activity of the aqueous leaf extract of Limonia elephantum was evaluated. The extract was administered orally 1,000 mg/kg to normal and alloxan-induced (55 mg/kg body weight, i.v) diabetic rats. The hypoglycemic effect of the extract was statistically significant with an oral dose of 1,000 mg/kg and was comparable to that of the effect produced by standard antidiabetic agent, metformin 1.5 mg/kg. The extract increased the glucose tolerance using oral glucose tolerance test.
Downloads
1396
822 Read
760
References
Anurag M, Sandeep A, Rajiv G, Manvi, Rajesh Kumar P, Ashish Kumar S. Effect of Feronia elephantum (Corr) Fruit pulp extract on indomethacin-induced gastric ulcer in albino rats. Tropical J Pharmaceut Res. 2009; 8: 509-14.
Deore SL, Khadabadi SS, Daulatkar VD, Deokate UA, Farooqui IU. Evaluation of hypoglycemic and antidiabetic activity of bark of Buteamonosperma. Phcog Mag. 2008; 4: 16-18.
Garg SC. Essential oil of Feronia elephantum Correa: A rich source of methyl chavicol. Indian Perfum. 2003; 47: 99-101.
Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethanopharmacol. 2002; 81: 81-100.
Gupta VC, Hussain SJ, Imam S. Important folk-medicinal plants and traditional knowledge of tribes of Aurangabad and Nasik forest divisions of Maharashtra (India). Hamdard Medic. 1997; 40: 59-61.
Hamdan N, Stephen JHA. Pharmacological characterization of the antihyperglycaemic properties of Tinospora crispa extract. J Ethanopharmacol. 1998; 62: 713.
Javed I, Mohammad A. Isolation of a flavonoid from Feronia limonia. J Saudi Chem Soc. 2009; 13: 29598.
Kamalakannan K, Balakrishnan V. Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Limonia elephantum leaves. Bangladesh J Pharmacol. 2014; 9: 383-88.
Kamalakannan K, Balakrishnan V. Ethanobotanical studies on Achyranthes Aspera Linn. among the folk peoples of Tamil Nadu, South India. J Phytol. 2009; 1: 108-11.
Kanhiya M, Anurag M, Ashok Kumar V. Preliminary pharma-cognostical and phytochemical investigation on Feronia elephantum Corr. Fruit. J Pharm Res. 2008; 1: 44-47.
Kar A, Choudhary BK, Bandyopadhyay NG. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethanopharmacol. 2003; 84: 105-08.
Kirtikar KR, Basu BD. Feronia elephantum Corr. Indian medicinal plants. Vol. I. L.M.B. Publishers, 1995, pp 496-98.
Paget GE, Barnes JM. Toxicity tests. In: Evaluation of drug activities: Pharmacometrics. Laurence DR, Bacharach AL (ed). London, Academic Press, 1964, pp 135-66.
Patil KMM, Zambare GN, Khandelwal KR, Bodhankar SL. Hepatoprotective activity of aqueous extract of leaves of Feronia elephantum Correa. against thioacetamide and allyl alcohol intoxication in rats. Toxicol Int. 2004; 11: 69-74.
Prince PS, Kamalakannan N, Menon VP. Antidiabetic and hyperlipedemic effect of alcoholic Syzigium cumini seeds in alloxan induced diabetic albino rats. J Ethanopharmacol. 2004; 91: 209-13.
Sarah W, Gojka R, Green A, Sicree R, King H. Global prevalence of diabetes. Diabetes Care. 2004; 27: 1047-53.
Wells BG, Dipiro JT, Schwinghammer TL, Dispiro CV. Diabetes mellitus. In: Pharmacotherapy handbook. 7th ed. Singapore, McGraw Hill, 2009, pp 210-26.
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
