GABAA receptor binding molecules from Traditional Chinese Medicine: An in silico approach

Authors

  • Meng Lv Department of Anesthesiology, Qianfoshan Hospital, Shandong University, Shandong 250014
  • Xue Tao Wang Department of Anesthesiology, Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong 250014
  • Kun Li Department of Gynaecology and Obstetrics, Affiliated Hospital of Shandong Academy of Medical Science, Shandong 250031
  • Yue Lan Wang Department of Anesthesiology, Qianfoshan Hospital, Shandong University, Shandong 250014

DOI:

https://doi.org/10.3329/bjp.v9i4.19731

Keywords:

GABAA, Traditional Chinese Medicine, Virtual Screening, Docking

Abstract

The advents of how anesthesia works have helped in the discovery of anesthetic target protein. One such target protein named ?-aminobutyric acid (GABAA), which is the chief inhibitory neurotransmitter in the mammalian central nervous system. Asparagine at 289 position of GABAA protein within TM2 is important for its anesthetic function. This study explores Traditional Chinese Medicine (TCM) against ASN 289 of GABAA for novel anesthetic compounds. The in silico approach showed gastrodin out of all compounds to be the best compound to start further analysis. It is a potential anesthetic compound suitable for the development of new drug.

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Author Biography

Yue Lan Wang, Department of Anesthesiology, Qianfoshan Hospital, Shandong University, Shandong 250014

Professor

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Published

2014-09-30

How to Cite

Lv, M., X. T. Wang, K. Li, and Y. L. Wang. “GABAA Receptor Binding Molecules from Traditional Chinese Medicine: An in Silico Approach”. Bangladesh Journal of Pharmacology, vol. 9, no. 4, Sept. 2014, pp. 447-51, doi:10.3329/bjp.v9i4.19731.

Issue

Vol. 9 No. 4 (2014)

Section

Research Articles

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