Biological activity of some novel synthesized 2-(4-methylbenzenesulphonamido)pentanedioic acid bis amide derivatives: In vitro and in vivo antineoplastic activity

Authors

  • Satyajit Dutta Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut 250001, Uttar Pradesh
  • Supratim Ray Department of Pharmaceutical Sciences, Assam University, Silchar 788011, Assam
  • K. Nagarajan Department of Pharmaceutical Chemistry, KIET School of Pharmacy, Muradnagar, Ghaziabad 201 206, Uttar Pradesh

DOI:

https://doi.org/10.3329/bjp.v9i4.19774

Keywords:

Anti-cancer, Earlich ascites carcinoma, Glutamic acid

Abstract

In the present work few novel 2-(4-methylbenzenesulphonamido)pentanedioic acid bis amide derivatives and the basic compound 2-(4-methylphenylsulfonamido)pentanedioic acid have been synthesized, characterized and screened for their possible antineoplastic activity both in vitro and in vivo. The in vitro activity was performed against five human cell lines like human breast cancer (MCF-7), leukemia (K-562), ovarian cancer (OVACAR-3), human colon adenocarcinoma (HT-29) and Human kidney carcinoma (A-498). The in vivo activity was performed in female swiss albino mice against Ehrlich ascites carcinoma (EAC). Among the synthesized compounds, ureide, anilide, p-nitoanilide and o-bromoanilide derivatives of 2-(4-methyl benzene sulphonyl)-pentanedioic acid bis amides showed encouraging activity in both the in vitro and in vivo compared to other compounds.

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Author Biographies

Supratim Ray, Department of Pharmaceutical Sciences, Assam University, Silchar 788011, Assam

Associate Professor and HOD

K. Nagarajan, Department of Pharmaceutical Chemistry, KIET School of Pharmacy, Muradnagar, Ghaziabad 201 206, Uttar Pradesh

Professor and HOD

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Published

2014-10-01

How to Cite

Dutta, S., S. Ray, and K. Nagarajan. “Biological Activity of Some Novel Synthesized 2-(4-methylbenzenesulphonamido)pentanedioic Acid Bis Amide Derivatives: In Vitro and in Vivo Antineoplastic Activity”. Bangladesh Journal of Pharmacology, vol. 9, no. 4, Oct. 2014, pp. 474-82, doi:10.3329/bjp.v9i4.19774.

Issue

Vol. 9 No. 4 (2014)

Section

Research Articles

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