Anticancer activity of Morus nigra leaves extract

Authors

  • Muhammad Imran Qadir Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan
  • Muhammad Ali Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan
  • Zubair Ibrahim College of Pharmacy, GC University, Faisalabad

DOI:

https://doi.org/10.3329/bjp.v9i4.19783

Keywords:

Anti-cancer, Morus nigra

Abstract

Plants are screened for treatment of many ailments including cancer because they possess certain potential constituents which are effective for treatment. The aim of this study was to evaluate the anticancer activity of Morus nigra leaves against human cervical cancer cell line (HeLa). n-Hexane and aqueous methanolic extract of plants leaves were made by maceration. Anticancer activity was estimated by methyl-thiazolyl-tetrazolium (MTT) assay and percentage inhibition of cells was calculated. Results of MTT showed that 100 µg/ml aqueous methanol extract of M. nigra inhibited 89.5-31.99% of HeLa cell line. It was concluded that M. nigra possess anticancer activity.

Downloads

Download data is not yet available.
Abstract
524
Download
281 Read
187

Author Biography

Muhammad Imran Qadir, Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan

Assistant Professor

References

Alesiani D, Canini A, DAbrosca B, DellaGreca M, Fiorentino A, Mastellone C, Pacifico S. Antioxidant and antiproliferative activities of phytochemicals from Quince Cydonia vulgaris peels. Food Chem. 2010; 118: 199-207.

Channabasava, Govindappa M. First report of anticancer agent, lapachol producing endophyte, Aspergillus niger of Tabebuia argentea and its in vitro cytotoxicity assays. Bangladesh J Pharmacol. 2014; 9: 129-39.

Cheng XL, Liu Q, Peng YB, Qi LW, Li P. Steamed ginger (Zingiber officinale): Changed chemical profile and increased anticancer potential. Food Chem. 2011; 129: 1785-92.

Dantu AS, Shankarguru P, Ramya DD, Vedha HB. Evaluation of in vitro anticancer activity of hydroalcoholic extract of Tabernaemontana divaricata. Asian J Pharm Clin Res. 2012; 5: 59-61.

Digrak M, Alma MH, ?lçim A, Sen S. Antibacterial and anti-fungal effects of various commercial plant extracts. Pharm Bio. 1999; 37: 216-20.

Ercisli S, Orhan E. Some physicochemical characteristics of black mulberry (Morusnigra L.) genotypes from northeast Anatolia region of Turkey. Scientia Horticulturae. 2008; 116: 41-46.

Imran M, Khan H, Shah M, Khan R, Khan F. Chemical composition and antioxidant activity of certain Morus species. J Zhejiang UniSci B. 2010; 11: 973-80.

Imran M, Talpur FN, Jan MI, Khan A, Khan I. Analysis of nutritional components of some wild edible plants. JCSP. 2007: 29: 500-08.

Mallhi TH, Qadir MI, Khan YH, Ali M. Hepatoprotective activity of aqueous methanolic extract of Morus nigra against paracetamol-induced hepatotoxicity in mice. Bangladesh J Pharmacol. 2014; 9: 60-66.

Saleem M, Qadir MI, Ahmad B, Saleem U, Naseer F, Schini-Kerth V, Ahmad M, Hussain K. Cytotoxic effect of ethanol extract of Convolvulus arvensis L (Convolvulaceae) on lymphoblastic leukemia Jurkat cells. Trop J Pharm Res. 2014; 13: 705-09.

Shafiq Y, Naqvi BS, Rizwani GH, Usman M, Shah BA, Aslam M, Hina B. Anti-acne activity of Casuarina equisetifolia bark extract: A randomized clinical trial. Bangladesh J Pharmacol. 2014; 9: 337-41.

Sundararajan P, Dey A, Smith A, Doss AG, Rajappan M, Natarajan S. Studies of anticancer and antipyretic activity of Bidens pilosa whole plant. Afric Health Sci. 2006; 6: 27-30.

Downloads

Additional Files

Published

2014-10-09

How to Cite

Qadir, M. I., M. Ali, and Z. Ibrahim. “Anticancer Activity of Morus Nigra Leaves Extract”. Bangladesh Journal of Pharmacology, vol. 9, no. 4, Oct. 2014, pp. 496-7, doi:10.3329/bjp.v9i4.19783.

Issue

Vol. 9 No. 4 (2014)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).