Periostin as a promising target of therapeutical intervention for colorectal cancer

Authors

  • Li Na Song China-Japan Union Hospital of Jilin University, Changchun 130033
  • Ling Xia Li China-Japan Union Hospital of Jilin University, Changchun 130033
  • Qing Hong Shi China-Japan Union Hospital of Jilin University, Changchun 130033
  • Ling Fang China-Japan Union Hospital of Jilin University, Changchun 130033
  • Li Sun China-Japan Union Hospital of Jilin University, Changchun 130033
  • Hai Feng Zhao The First Affiliated Hospital of Jiamusi University, Jiamusi 154003
  • Ning Liu The Second Hospital of Jilin University, Changchun 130021
  • Hong Jun Li China-Japan Union Hospital of Jilin University, Changchun 130033
  • Cheng Yan He China-Japan Union Hospital of Jilin University, Changchun 130033

DOI:

https://doi.org/10.3329/bjp.v9i4.19921

Keywords:

Colorectal cancer, Periostin, siRNA

Abstract

The expression of periostin in the tissue of colorectal cancer patients and its correlation with clinical features were studied. Periostin expression was ~4 fold up-regulated in cancer tissues compared to adjacent non-cancerous tissues. Serum levels of periostin in patients were significantly elevated to 32.6 ± 10.8 ng/mL vs 20.4 ± 11.1 ng/mL in healthy volunteers. Higher preoperative serum periostin levels in patients were closely related to advanced-stage disease (stage III/IV), distant and lymph nodes metastasis. High level of periostin expression was detected in the SW480 human colon carcinoma cells, and could be down-regulated by small interfering RNAs (siRNA). The siRNA-mediated knockdown of periostin arrested the cell cycle at G0/G1 phase and induced apoptotic cell death in the SW480 cells. In conclusion, periostin is a promising prognostic and therapeutic target for colorectal cancer.

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Published

2014-10-02

How to Cite

Song, L. N., L. X. Li, Q. H. Shi, L. Fang, L. Sun, H. F. Zhao, N. Liu, H. J. Li, and C. Y. He. “Periostin As a Promising Target of Therapeutical Intervention for Colorectal Cancer”. Bangladesh Journal of Pharmacology, vol. 9, no. 4, Oct. 2014, pp. 488-95, doi:10.3329/bjp.v9i4.19921.

Issue

Vol. 9 No. 4 (2014)

Section

Research Articles

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